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Sexually Transmitted Infections

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Secondary Syphilis: a Histopathological Study.

R K Basumatary, Ratan Singh

Indian Journal of Dermatology, Venereology and Leprology

|February 21, 2017

Summary

This summary is machine-generated.

Histopathological examination of secondary syphilis biopsies revealed classic patterns in most cases, but 22.72% showed inconspicuous or absent signs. Early stages may present with granulomatous reactions and various epidermal changes.

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Area of Science:

Dermatopathology
Infectious Diseases

Background:

Secondary syphilis, a systemic stage of syphilis infection, presents with diverse clinical manifestations.
Histopathological analysis is crucial for diagnosing syphilis, especially when clinical signs are atypical.

Purpose of the Study:

To investigate and characterize the histopathological patterns observed in biopsies from patients with secondary syphilis.
To identify the frequency of specific epidermal and dermal changes in secondary syphilis.

Main Methods:

Analysis of 44 biopsies from 31 confirmed cases of secondary syphilis.
Detailed examination of histopathological features, including epidermal alterations and inflammatory responses.

Main Results:

The classical histopathological picture of syphilis was present in the majority of cases.
Atypical or inconspicuous syphilitic patterns were noted in 22.72% of biopsies.
Granulomatous reactions occurred in 15.9% of early-stage cases.
Frequent epidermal changes included hypokeratosis, parakeratosis, exocytosis, spongiosis, and acanthosis.
Basal cell degeneration was observed in 33.63% of cases, with keratotic plugging in 11.36% and hypergranulosis in 2.27%.

Conclusions:

While classic histopathological findings are common in secondary syphilis, a significant proportion of cases exhibit less typical patterns.
Recognizing a spectrum of epidermal changes and occasional granulomatous reactions is important for accurate diagnosis, particularly in early disease stages.