Depigmenting Erythema Multiforme

Two patients with a peculiar variant of erythema multiforme are described. The classical iris lesions, appearing seasonally in response to as yet unidentifiable agents, resolved leaving behind persistent depigmentation. Although, the EM lesions aborted on cordcosteroid therapy, the latter seemed to have no effect on the depigmented spots. The histopathological features were characteristic of EM. The depigmentafion perhaps is the result of a permanent damage to the melanocytes. This variant of EM may be tentatively designated as depigmenting erythema multifome - DEM.