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Updated: Mar 7, 2026

Optimization of the Ugi Reaction Using Parallel Synthesis and Automated Liquid Handling
Published on: November 11, 2008
N-Hydroxyimide Ugi Reaction toward α-Hydrazino Amides
Ajay L Chandgude1, Alexander Dömling1
1Department of Drug Design, University of Groningen , Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands.
Abstract:
The Ugi four-component reaction (U-4CR) with N-hydroxyimides as a novel carboxylic acid isostere has been reported. This reaction provides straightforward access to α-hydrazino amides. A broad range of aldehydes, amines, isocyanides and N-hydroxyimides were employed to give products in moderate to high yields. This reaction displays N-N bond formation by cyclic imide migration in the Ugi reaction. Thus, N-hydroxyimide is added as a new acid component in the Ugi reaction and broadens the scaffold diversity.
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