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Using Multi-fluorinated Bile Acids and In Vivo Magnetic Resonance Imaging to Measure Bile Acid Transport
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Bile acids and cardiovascular function in cirrhosis

Andrei Voiosu1,2,3, Signe Wiese1,4, Theodor Voiosu2,3

  • 1Department of Clinical Physiology and Nuclear Medicine, Center for Functional and Diagnostic Imaging and Research, Hvidovre Hospital, Hvidovre, Denmark.

Liver International : Official Journal of the International Association for the Study of the Liver
|February 22, 2017
PubMed

Insights

Bile acids contribute to cardiovascular dysfunction in cirrhosis by altering signaling pathways. Targeting bile acid receptors may offer new therapeutic strategies for cirrhotic cardiomyopathy and hyperdynamic syndrome.

Area of Science:

  • Cardiology
  • Hepatology
  • Pharmacology

Background:

  • Cirrhotic cardiomyopathy and hyperdynamic syndrome are significant complications of cirrhosis with unclear pathogenesis.
  • Bile acids are implicated in cardiovascular dysfunction, with emerging evidence on their receptor-mediated effects.

Purpose of the Study:

  • To review the role of bile acids and their receptors in cardiovascular dysfunction in cirrhosis.
  • To explore potential therapeutic targets related to bile acid signaling.

Main Methods:

  • Literature review of experimental models and recent studies on bile acids and cardiovascular function in cirrhosis.
  • Analysis of bile acid receptor functions (FXR, TGR5) in cardiovascular cells.

Main Results:

  • Bile acids exert cardiotoxic effects and disrupt cellular metabolism via receptor signaling.
  • Chronic cholestasis leads to abnormal bile acid levels, altering signaling and causing cardiovascular disturbances.

Conclusions:

  • Bile acids and their receptors are key players in the development of cardiovascular dysfunction in cirrhosis.
  • Targeting bile acid receptors presents a promising therapeutic avenue for managing these complications.

Keywords:
bile acidscholestasiscirrhosiscirrhotic cardiomyopathyfarnesoid X-activated receptorhemodynamicsursodeoxycholic acid

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