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Related Concept Videos

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Chronic liver disease significantly impacts drug metabolism due to alterations in hepatic blood flow and enzyme accessibility. This disruption affects the body's pharmacokinetics—the movement and processing of drugs within the system. Key enzymes crucial for metabolizing medications become less accessible, changing how drugs are processed and utilized. Furthermore, liver disease influences the synthesis of plasma proteins, such as albumin and globulins, which play critical roles in drug...
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In clinical practice, the direct measurement of hepatic blood flow to evaluate liver function presents significant challenges due to the intricate and specialized nature of the necessary techniques. Consequently, healthcare professionals often rely on empirical estimates derived from thorough patient examinations and liver function tests to gauge liver health. Among the tools at their disposal, the Child–Pugh and MELD scoring systems stand out for their ability to categorize and assess...
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Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
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Related Experiment Video

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Bile acids and cardiovascular function in cirrhosis.

Andrei Voiosu1,2,3, Signe Wiese1,4, Theodor Voiosu2,3

  • 1Department of Clinical Physiology and Nuclear Medicine, Center for Functional and Diagnostic Imaging and Research, Hvidovre Hospital, Hvidovre, Denmark.

Liver International : Official Journal of the International Association for the Study of the Liver
|February 22, 2017
PubMed
Summary

Bile acids contribute to cardiovascular dysfunction in cirrhosis by altering signaling pathways. Targeting bile acid receptors may offer new therapeutic strategies for cirrhotic cardiomyopathy and hyperdynamic syndrome.

Keywords:
bile acidscholestasiscirrhosiscirrhotic cardiomyopathyfarnesoid X-activated receptorhemodynamicsursodeoxycholic acid

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Area of Science:

  • Cardiology
  • Hepatology
  • Pharmacology

Background:

  • Cirrhotic cardiomyopathy and hyperdynamic syndrome are significant complications of cirrhosis with unclear pathogenesis.
  • Bile acids are implicated in cardiovascular dysfunction, with emerging evidence on their receptor-mediated effects.

Purpose of the Study:

  • To review the role of bile acids and their receptors in cardiovascular dysfunction in cirrhosis.
  • To explore potential therapeutic targets related to bile acid signaling.

Main Methods:

  • Literature review of experimental models and recent studies on bile acids and cardiovascular function in cirrhosis.
  • Analysis of bile acid receptor functions (FXR, TGR5) in cardiovascular cells.

Main Results:

  • Bile acids exert cardiotoxic effects and disrupt cellular metabolism via receptor signaling.
  • Chronic cholestasis leads to abnormal bile acid levels, altering signaling and causing cardiovascular disturbances.

Conclusions:

  • Bile acids and their receptors are key players in the development of cardiovascular dysfunction in cirrhosis.
  • Targeting bile acid receptors presents a promising therapeutic avenue for managing these complications.