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Antimicrobial Use for and Resistance of Zoonotic Bacteria Recovered from Nonhuman Primates

Jeffrey Kim1, Dondrae J Coble2, Gregory W Salyards3

  • 1Department of Veterinary Preventive Medicine, College of Veterinary Medicine, College of Public Health, The Ohio State University, Columbus, Ohio.

Comparative Medicine
|February 23, 2017
PubMed

Insights

Antimicrobial resistance (AMR) in non-human primates (NHP) is understudied. This research found zoonotic bacteria from NHP are generally susceptible to common treatments, aiding veterinary care and staff safety.

Area of Science:

  • Veterinary Medicine
  • Microbiology
  • Public Health
  • Antimicrobial Resistance (AMR)

Background:

  • Antimicrobial resistance (AMR) poses a significant threat to human and animal health globally.
  • Established surveillance systems like the National Antimicrobial Resistance Monitoring System (NARMS) exist, but data on AMR in non-human primates (NHP) is limited.
  • Understanding AMR in NHP is crucial due to their role in biomedical research and potential for zoonotic disease transmission.

Purpose of the Study:

  • To assess antimicrobial use strategies and the prevalence of AMR in zoonotic bacteria from NHP in research settings.
  • To provide data to guide effective antimicrobial therapy in NHP and minimize occupational risks for researchers and veterinarians.

Main Methods:

  • Analysis of antimicrobial susceptibility test results for four enteric bacteria (Shigella flexneri, Yersinia enterocolitica, Y. pseudotuberculosis, Campylobacter jejuni) from NHP.
  • Data collected from 15 veterinarians, 7 research institutions, and 4 diagnostic labs between January 2012 and April 2015.
  • Comparison of resistance patterns between NHP isolates and human isolates from NARMS.

Main Results:

  • While isolates were susceptible to primary treatments, significant resistance was observed to other antimicrobials: S. flexneri (erythromycin, doxycycline, tetracycline), Y. enterocolitica (ampicillin, cefazolin), and C. jejuni (methicillin, cephalothin).
  • No resistance was found in Y. pseudotuberculosis isolates.
  • AMR patterns in NHP isolates did not mirror those found in human isolates reported by NARMS.

Conclusions:

  • Zoonotic bacteria recovered from NHP diagnostic samples demonstrate broad susceptibility to antimicrobials used for clinical infections.
  • Findings support veterinarians in selecting effective antimicrobial treatments for NHP.
  • This data helps mitigate occupational health risks associated with zoonotic bacteria in research environments.

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