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Inhibitory effect of disulfiram (Antabuse) on alcohol dehydrogenase activity
W R Carper1, R C Dorey, J H Beber
1Department of Psychiatry, Veteran's Administration Medical Center, Wichita, KS 67218.
Clinical Chemistry
|October 1, 1987
Abstract:
We investigated the effect of disulfiram (Antabuse) on the activity of alcohol dehydrogenase (EC 1.1.1.1) in vitro. We observed a time-dependent inhibition of this dehydrogenase by disulfiram and diethyldithiocarbamate similar to that obtained for aldehyde dehydrogenase (EC 1.2.1.3). These results suggest a possible explanation for various side effects observed in the clinical use of Antabuse.