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Intranasal trigeminal function in patients with empty nose syndrome
Iordanis Konstantinidis1, Evangelia Tsakiropoulou1, Angelos Chatziavramidis1
1Rhinology Clinic, 2nd Academic Otorhinolaryngology Department, Papageorgiou Hospital, Aristotle University, Thessaloniki, Greece.
The Laryngoscope
|February 23, 2017
Summary
Empty nose syndrome (ENS) patients exhibit impaired trigeminal nerve function, affecting nasal airflow perception. This dysfunction is linked to paradoxical nasal obstruction sensation in ENS, distinct from standard turbinate surgery outcomes.
Area of Science:
- Otolaryngology
- Neuroscience
- Sensory Physiology
Background:
- The trigeminal nerve is crucial for sensing nasal airflow.
- Empty Nose Syndrome (ENS) is characterized by a paradoxical sensation of nasal obstruction.
- The role of intranasal trigeminal nerve function in ENS remains unclear.
Purpose of the Study:
- To investigate whether impaired intranasal trigeminal function contributes to the sensation of nasal obstruction in patients with ENS.
- To compare trigeminal function in ENS patients with individuals who underwent turbinate removal without ENS symptoms and healthy controls.
Main Methods:
- A prospective case-control study was conducted with 71 participants: 21 ENS patients, 18 patients with prior inferior turbinate removal (ITR) without ENS, and 31 controls.
- Participants underwent active anterior rhinomanometry, olfactory testing (extended Sniffin' Sticks), and trigeminal testing (menthol/solvent lateralization task).
Main Results:
- ENS patients demonstrated significantly poorer trigeminal lateralization test scores compared to both ITR patients and controls.
- Olfactory testing scores were also significantly lower in the ENS group than in controls.
- No significant differences in rhinomanometry were observed between the groups; trigeminal test results showed a negative correlation with age.
Conclusions:
- Intranasal trigeminal nerve function is significantly impaired in patients with Empty Nose Syndrome.
- These findings suggest a potential link between trigeminal dysfunction and the characteristic nasal obstruction sensation in ENS.
- Further research is warranted to explore preoperative trigeminal function and the surgical impact on this impairment.
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