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Related Concept Videos

Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

294
Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
294
Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

334
Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
334
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution01:00

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

306
Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are...
306
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism

283
Geriatric patients show significant variation in how their bodies process medications, which can change how effective and safe treatments are. The liver is the primary organ where drug metabolism occurs, involving two main types of chemical reactions: phase I and II. Phase I metabolism is driven by the cytochrome P450 enzyme system, which includes key types such as CYP3A, CYP2D6, and CYP2C9. Research indicates that while aging doesn't notably alter the levels or activity of these enzymes, it...
283
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption01:22

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

771
As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
771
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion

294
In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...
294

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Updated: Mar 7, 2026

Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder
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[Alcohol intoxication in old age].

Pascal Menecier1, Loetita Rotheval2

  • 1Centre hospitalier de Mâcon, boulevard Louis-Escande, 71018 Mâcon cedex, France; Institut de psychologie, Université Lyon 2, 5 avenue Pierre-Mendès-France, Campus Porte des Alpes, 69500 Bron, France.

Soins. Gerontologie
|February 23, 2017
PubMed
Summary
This summary is machine-generated.

Elderly individuals are more susceptible to alcohol intoxication, experiencing symptoms like falls and confusion. Treatment for alcohol addiction is possible for older adults, and discussing drinking habits after an episode is beneficial.

Keywords:
acute alcohol intoxicationalcoholalcoolcareelderly personintoxication éthylique aiguëmisusemésusagesoinssujet âgé

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Area of Science:

  • Geriatric Medicine
  • Toxicology
  • Public Health

Background:

  • Acute alcohol intoxication presents unique challenges in elderly populations.
  • Older adults exhibit increased vulnerability to alcohol's effects, requiring lower doses for intoxication.
  • Common clinical manifestations include falls, dizziness, and confusion.

Purpose of the Study:

  • To highlight the heightened susceptibility of the elderly to alcohol intoxication.
  • To emphasize that age is not a barrier to alcohol addiction treatment.
  • To recommend timely intervention and discussion following intoxication episodes.

Main Methods:

  • Clinical observation of acute alcohol intoxication in geriatric patients.
  • Review of alcohol's physiological impact on the aging population.
  • Analysis of treatment accessibility for alcohol addiction in older adults.

Main Results:

  • Elderly individuals require less alcohol to reach intoxication levels.
  • Symptoms such as falls, dizziness, and confusion are common indicators.
  • Alcohol addiction treatment remains a viable option for geriatric patients.

Conclusions:

  • Geriatric patients are uniquely vulnerable to acute alcohol intoxication.
  • Early intervention and open communication are crucial for managing alcohol-related issues in the elderly.
  • Age should not preclude older adults from seeking or receiving alcohol addiction treatment.