The aplication of cyanoacrilate surgical glue on skin suture in rats
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Published on: December 23, 2014
João Ilgenfritz1, Ricardo Dutra Aydos2, Iandara Schettert Silva3
1Fellow PhD degree, Postgraduate Program in Health and Development, Universidade Federal do Mato Grosso do Sul (UFMS), Campo Grande-MS, Brazil. Analysis and interpretation of data, manuscript writing.
Purpose::
To compare the use of a new cyanoacrylate-based surgical glue and suture with sepa-rate points in skin wounds closure.
Methods::
Thirty-six rats were subjected to a 4cm dorsal longitudinal incision. Twelve were sub-jected to simple suture with polyamide 6-0, 12 rats underwent wall synthesis using Dermabond(r) and 12 was performed cutaneous synthesis with N-2-Butyl-Cyanoacrylate. Twelve of each group was euthanized on the seventh postoperative day, their blood was taken to biochemical tests and a layer of skin and subcutaneous tissue surrounding the surgical scar was randomly divided in two segments, to the submission of tension tests and to histological study.
Results::
There were no significant difference between groups (p>0.05). In the soft dermis there was more type I collagen production in group I (p<0.05), group II and III was similar re-sults (p>0.05). In the compact dermis, all 3 groups showed similar results (p>0.05). The biomechanical study was similarity between the glue groups (p>0.05) but the group III proved to be different from the others having a higher resistance (p>0.05) .
Conclusion::
This glue does not cause any inflammation or kidney and hepatic toxicity. Polyamide sutures are more resistant and the glue should be used alone only in less tension are-as.
