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Updated: Mar 7, 2026

A 3D Organotypic Melanoma Spheroid Skin Model
Published on: May 18, 2018
Synchronous melanomas arising within nevus spilus
Maria Helena Toda Sanches de Brito1, Cecília Silva Nunes de Moura Dionísio2, Cândida Margarida Branco Martins Fernandes3
1Department of Dermatology, Santarém Hospital - Santarém, Portugal.
Abstract:
Nevus spilus is a melanocytic cutaneous lesion consisting of a light brown background macule with numerous superimposed darker maculopapular speckles. Melanoma arising from a nevus spilus is rare, with less than 40 cases reported to date. The absolute risk for malignant transformation is not well defined, lacking a standardized management approach. We report a new case of melanoma arising from nevus spilus, with the additional peculiarity of multifocality. We offer our recommendations for the management of the condition.
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