Related Experiment Video
Updated: Aug 1, 2026

Preparation, Purification, and Characterization of Lanthanide Complexes for Use as Contrast Agents for Magnetic Resonance Imaging
Published on: July 21, 2011
The effect of the reduction method on the composition of 99mTc-EHDP complexes
G J de Groot1, H A Das, C L de Ligny
1Netherlands Energy Research Foundation (ECN), Chemistry Department, Petten, N.H.
Abstract:
The composition of 99mTc-ethane-1-hydroxy-1, 1-diphosphonate complexes, prepared with the reducing agent NaBH4 and by electrolytic reduction, was analysed by reversed-phase ion-pair chromatography and soft-gel permeation chromatography. The results were compared with corresponding data for complexes prepared with the traditional reducing agent tin(II). Significant differences between the chromatograms of the three preparations were found. They were interpreted in terms of the occurrence of different complexes in the three preparations.
Related Concept Videos
¹³C NMR: Distortionless Enhancement by Polarization Transfer (DEPT)
EDTA: Chemistry and Properties
EDTA: Auxiliary Complexing Reagents
Complexometric EDTA Titration Curves
Effects of EDTA on End-Point Detection Methods
In the visual method, metal-ion indicators (metallochromic dyes), which have distinct colors in their free and complex forms, are added to the mixture to signal the titration's end point. They form stable complexes with metal ions, but these complexes are weaker than the corresponding metal–EDTA complexes. As a result, EDTA...
Masking and Demasking Agents
There are many masking agents, such as cyanide, fluoride, triethanolamine, thiourea, and 2,3-bis(sulfanyl)propan-1-ol (formerly 2,3-dimercapto-1-propanol), with the masking agent chosen based on the metal...

