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Compliments of Factor H: What's in it for AMD?
Mary J Mattapallil1, Rachel R Caspi1
1National Eye Institute, Bethesda, MD 20892, USA.
Immunity
|February 24, 2017
Abstract
None:
Genetic variations in complement factor H (CFH) confer greater risk for age-related macular degeneration (AMD). In this issue of Immunity, Calippe et al. (2017) uncover a non-canonical role for CFH in the inhibition of mononuclear phagocyte elimination from sub-retinal lesions, providing insight into the pathophysiology of AMD associated with CFH variants.

