Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

4.0K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
4.0K
Aging01:26

Aging

924
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
924
Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

294
Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
294
Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

334
Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
334
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution01:00

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

306
Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are...
306
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism

283
Geriatric patients show significant variation in how their bodies process medications, which can change how effective and safe treatments are. The liver is the primary organ where drug metabolism occurs, involving two main types of chemical reactions: phase I and II. Phase I metabolism is driven by the cytochrome P450 enzyme system, which includes key types such as CYP3A, CYP2D6, and CYP2C9. Research indicates that while aging doesn't notably alter the levels or activity of these enzymes, it...
283

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Physiological Responses to Four Different Baseline Accelerations on a Human Centrifuge.

Aerospace medicine and human performance·2026
Same author

Exercise and functional integrity in non-disease and disease states during human ageing: the relevance of VO<sub>2max</sub>.

Free radical biology & medicine·2025
Same author

Preliminary considerations for accessible space missions for all.

NPJ microgravity·2025
Same author

Insights into human muscle biology from human primary skeletal muscle cell culture.

Journal of muscle research and cell motility·2025
Same author

Author Correction: Effect of gut microbiome modulation on muscle function and cognition: the PROMOTe randomised controlled trial.

Nature communications·2025
Same author

Global consensus on optimal exercise recommendations for enhancing healthy longevity in older adults (ICFSR).

The journal of nutrition, health & aging·2025
Same journal

Evolution of Adaptive Non-Shivering Thermogenesis in Mammals.

Physiology (Bethesda, Md.)·2026
Same journal

The Iron Lung: Ferroptosis and Iron Regulation in Aging and Lung Diseases.

Physiology (Bethesda, Md.)·2026
Same journal

RNA-Protein complexes and their role in cell fate.

Physiology (Bethesda, Md.)·2026
Same journal

Ion Channels as Gatekeepers of Fertility: From Uterine Kir7.1 to Sperm CatSper.

Physiology (Bethesda, Md.)·2026
Same journal

Is insulin resistance an adaptive response? Clues from nature.

Physiology (Bethesda, Md.)·2026
Same journal

Physiology in Perspective.

Physiology (Bethesda, Md.)·2026
See all related articles

Related Experiment Video

Updated: Mar 7, 2026

Walk with Me Hybrid Virtual/In-Person Walking for Older Adults with Neurodegenerative Disease
07:21

Walk with Me Hybrid Virtual/In-Person Walking for Older Adults with Neurodegenerative Disease

Published on: June 16, 2023

1.6K

Physical Activity, Aging, and Physiological Function.

Stephen D R Harridge1, Norman R Lazarus2

  • 1Centre of Human & Aerospace Physiological Sciences, Faculty of Life Sciences & Medicine, King's College London, London, United Kingdom s.harridge@kcl.ac.uk.

Physiology (Bethesda, Md.)
|February 24, 2017
PubMed
Summary
This summary is machine-generated.

Physical activity is essential for optimal health and aging. Inactivity negatively impacts health, while regular exercise allows the natural aging process to occur without disuse complications, leading to better function and well-being.

More Related Videos

Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People
12:59

Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People

Published on: July 5, 2017

13.3K
Getting to Compliance in Forced Exercise in Rodents: A Critical Standard to Evaluate Exercise Impact in Aging-related Disorders and Disease
10:19

Getting to Compliance in Forced Exercise in Rodents: A Critical Standard to Evaluate Exercise Impact in Aging-related Disorders and Disease

Published on: August 22, 2014

14.7K

Related Experiment Videos

Last Updated: Mar 7, 2026

Walk with Me Hybrid Virtual/In-Person Walking for Older Adults with Neurodegenerative Disease
07:21

Walk with Me Hybrid Virtual/In-Person Walking for Older Adults with Neurodegenerative Disease

Published on: June 16, 2023

1.6K
Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People
12:59

Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People

Published on: July 5, 2017

13.3K
Getting to Compliance in Forced Exercise in Rodents: A Critical Standard to Evaluate Exercise Impact in Aging-related Disorders and Disease
10:19

Getting to Compliance in Forced Exercise in Rodents: A Critical Standard to Evaluate Exercise Impact in Aging-related Disorders and Disease

Published on: August 22, 2014

14.7K

Area of Science:

  • Human evolutionary biology
  • Gerontology
  • Exercise physiology

Background:

  • Human evolution indicates physical activity is the natural state for health.
  • Sedentary lifestyles have detrimental health consequences throughout life.
  • Disuse complications significantly impair physiological function during aging.

Purpose of the Study:

  • To examine the impact of physical activity on the aging process.
  • To differentiate between aging-related decline and inactivity-induced decline.
  • To highlight the benefits of an active lifestyle for healthspan and well-being.

Main Methods:

  • Comparative analysis of physiological function in active versus inactive aging populations.
  • Review of evolutionary and physiological data on human activity levels.
  • Longitudinal study design to track health and function over time (implied).

Main Results:

  • Physically active individuals experience aging with fewer disuse complications.
  • Inactivity exacerbates age-related physiological decline.
  • Optimal health, well-being, and aging are associated with sustained physical activity.

Conclusions:

  • Physical activity is crucial for mitigating negative health effects associated with aging.
  • Maintaining an active lifestyle supports superior physiological function and quality of life in older age.
  • The inherent aging process is best supported by a foundation of consistent physical activity.