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Relationship Between γ-Glutamyltransferase Levels and Left Ventricular Diastolic Dysfunction.

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Higher serum gamma-glutamyltransferase (GGT) levels are associated with left ventricular (LV) diastolic dysfunction and LV hypertrophy in adults. This finding highlights a potential link between GGT and cardiac abnormalities.

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Area of Science:

  • Cardiology
  • Biochemistry
  • Public Health

Background:

  • Serum gamma-glutamyltransferase (GGT) is an enzyme linked to various health conditions.
  • Left ventricular (LV) diastolic dysfunction and hypertrophy are significant indicators of cardiac health.

Purpose of the Study:

  • To investigate the association between serum GGT levels and the presence of LV diastolic dysfunction and LV hypertrophy.
  • To explore potential correlations in a large population cohort.

Main Methods:

  • A cross-sectional study involving 79,459 Korean adults who underwent echocardiography.
  • LV diastolic dysfunction and hypertrophy were diagnosed via echocardiography.
  • Statistical analysis included multivariable adjustments and interaction analysis with age.

Main Results:

  • Elevated serum GGT levels were significantly associated with both LV diastolic dysfunction and LV hypertrophy.
  • Odds ratios for LV diastolic dysfunction increased with higher GGT quartiles (OR 2.23 for highest quartile).
  • Odds ratios for LV hypertrophy also showed a trend with higher GGT levels (P for trend = 0.01).

Conclusions:

  • A positive association exists between serum GGT levels and LV diastolic dysfunction and hypertrophy.
  • This relationship was observed independently of potential confounding factors.
  • Age was found to modify the association between GGT and cardiac abnormalities.