Related Experiment Video

Updated: Mar 7, 2026

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data
10:46

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data

Published on: December 9, 2015

11.2K

Pediatric Hypovitaminosis D: Molecular Perspectives and Clinical Implications

Rafiu Ariganjoye1

  • 1Dr. Sulaiman Al-Habib Medical Group Al Takhassusi Hospital, Riyadh, Kingdom of Saudi Arabia.

Global Pediatric Health
|February 24, 2017
PubMed

Insights

Vitamin D deficiency is common in children and linked to serious health issues like bone disease, infections, and autoimmune conditions. Understanding its molecular basis is key to addressing these widespread pediatric health concerns.

Area of Science:

  • Pediatric Endocrinology
  • Nutritional Science
  • Molecular Biology

Background:

  • Vitamin D is crucial for bone health in children and adults.
  • Low 25-hydroxy vitamin D (25-(OH)-D) levels are prevalent globally in pediatric populations.
  • Hypovitaminosis D is associated with numerous adverse health outcomes.

Purpose of the Study:

  • To review the molecular aspects of vitamin D deficiency in children.
  • To summarize the potential adverse health outcomes linked to vitamin D deficiency in pediatric age groups.

Main Methods:

  • Literature review focusing on molecular mechanisms.
  • Synthesis of data on health outcomes associated with vitamin D deficiency.

Main Results:

  • Vitamin D deficiency is linked to rickets, osteomalacia, growth retardation, and neurological issues like autism.
  • Increased risk of cardiovascular diseases, diabetes, cancers, infectious diseases, and autoimmune disorders (e.g., multiple sclerosis).
  • Identified risk factors include dark skin, low sun exposure, obesity, and certain medical conditions.

Conclusions:

  • Vitamin D deficiency poses significant health risks to children worldwide.
  • Understanding the molecular pathways is essential for addressing deficiency-related pediatric diseases.
  • Further research into molecular perspectives can guide future interventions.

Keywords:
endocrinologygeneral pediatricsmedical education

More Related Videos

In Vivo Augmentation of Gut-Homing Regulatory T Cell Induction08:02

In Vivo Augmentation of Gut-Homing Regulatory T Cell Induction

Published on: January 22, 2020

6.0K
Generation of Immature, Mature and Tolerogenic Dendritic Cells with Differing Metabolic Phenotypes06:09

Generation of Immature, Mature and Tolerogenic Dendritic Cells with Differing Metabolic Phenotypes

Published on: June 22, 2016

24.1K

Related Concept Videos

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption01:23

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption

Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
575
Pharmacokinetics in Pediatric Patients: Drug Metabolism01:24

Pharmacokinetics in Pediatric Patients: Drug Metabolism

In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses...
304
Pharmacokinetics in Pediatric Patients: Drug Distribution01:17

Pharmacokinetics in Pediatric Patients: Drug Distribution

Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight,...
405
Drug Dosing: Infants and Children01:29

Drug Dosing: Infants and Children

Pediatric patient dosages diverge from adults due to disparities in body surface area, total body water, and extracellular fluid per kilogram of body weight. The dosing regimen considers the variations in pharmacokinetics and pharmacology across distinct age groups, encompassing preterm newborns, infants, young children, older children, and adolescents. Calculation of pediatric patient doses is predicated on determining body surface area, which exhibits a superior correlation with the child's...
615
Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
342
Role of Skin in Vitamin D Synthesis01:23

Role of Skin in Vitamin D Synthesis

The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...
8.5K