Characterizing biomarkers in osteosarcoma metastasis based on an ego-network
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Updated: Mar 7, 2026
Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma
Published on: April 12, 2019
1Department of Orthopaedics, Heze Municipal Hospital, Caozhou Road, Heze, 274031, Shandong, People's Republic of China.
Objectives:
To characterize biomarkers that underlie osteosarcoma (OS) metastasis based on an ego-network.
Results:
From the microarray data, we obtained 13,326 genes. By combining PPI data and microarray data, 10,520 shared genes were found and constructed into ego-networks. 17 significant ego-networks were identified with p < 0.05. In the pathway enrichment analysis, seven ego-networks were identified with the most significant pathway.
Conclusions:
These significant ego-modules were potential biomarkers that reveal the potential mechanisms in OS metastasis, which may contribute to understanding cancer prognoses and providing new perspectives in the treatment of cancer.
