Associations Among Infant Iron Deficiency, Childhood Emotion and Attention Regulation, and Adolescent Problem Behaviors
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Updated: Mar 7, 2026

Psychophysiological Assessment of the Effectiveness of Emotion Regulation Strategies in Childhood
Published on: February 11, 2017
Patricia East1, Erin Delker1, Betsy Lozoff2
1University of California, San Diego.
Insights
Infant iron deficiency anemia (IDA) is linked to adolescent problem behaviors like risky sex and alcohol use. This occurs through impaired childhood emotion regulation and attention, affecting long-term adjustment.
Area of Science:
- Developmental Psychology
- Pediatric Health
- Neuroscience
Background:
- High rates of iron deficiency (28%) and iron-deficiency anemia (17%) were observed in Chilean infants born between 1991-1996.
- This period predates national iron fortification programs, offering a unique study population.
Purpose of the Study:
- To investigate if infant iron deficiency (ID) influences adolescent problem behaviors.
- To determine if poor childhood regulatory abilities mediate the relationship between infant ID and adolescent outcomes.
Main Methods:
- Longitudinal study of 1,116 Chilean infants from infancy through adolescence (ages 10 and 14).
- Assessment of iron deficiency anemia (IDA) in infancy.
- Evaluation of emotion regulation and attentional control in childhood.
- Measurement of problem behaviors (alcohol use, risky sexual behavior, risk-taking) in adolescence.
Main Results:
- Infant IDA was significantly associated with excessive alcohol use and risky sexual behavior in adolescence.
- Poor emotion regulation in childhood was identified as a key mediator.
- Attentional control deficits at age 10 linked infant IDA to adolescent risk-taking.
Conclusions:
- Infant iron deficiency anemia can have lasting impacts on adolescent behavioral adjustment.
- Childhood regulatory abilities play a crucial role in how infant IDA affects long-term outcomes.
- Findings highlight the importance of early iron status for cognitive and emotional development.
Abstract:
This study examined whether iron deficiency (ID) in infancy contributes to problem behaviors in adolescence through its influence on poor regulatory abilities in childhood. Chilean infants (N = 1,116) were studied when there was no national program for iron fortification (1991-1996), resulting in high rates of ID (28%) and iron-deficiency anemia (IDA, 17%). Infants (54% male) were studied at childhood (Mage = 10 years) and adolescence (Mage = 14 years). IDA in infancy was related to excessive alcohol use and risky sexual behavior in adolescence through its effect on poor emotion regulation in childhood. Attentional control deficits at age 10 were also related to both infant IDA and heightened risk taking in adolescence. Findings elucidate how poor childhood regulatory abilities associated with infant IDA compromise adjustment in adolescence.
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