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Related Concept Videos

Pulmonary Tuberculosis IV01:26

Pulmonary Tuberculosis IV

588
Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
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Pulmonary Tuberculosis III01:31

Pulmonary Tuberculosis III

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Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
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Pulmonary Tuberculosis II01:28

Pulmonary Tuberculosis II

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Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
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Pulmonary Tuberculosis I01:29

Pulmonary Tuberculosis I

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Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
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Pulmonary Tuberculosis V01:28

Pulmonary Tuberculosis V

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Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
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Skin Diseases and Disorders01:23

Skin Diseases and Disorders

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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
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Related Experiment Video

Updated: Mar 7, 2026

Analysis of 18FDG PET/CT Imaging as a Tool for Studying Mycobacterium tuberculosis Infection and Treatment in Non-human Primates
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Cutaneous Tuberculosis.

Michael K Hill1, Charles V Sanders2

  • 1Saint Tammany Parish Hospital, Covington, LA 70433.

Microbiology Spectrum
|February 25, 2017
PubMed
Summary

Cutaneous tuberculosis (TB) presents with diverse skin manifestations. Early suspicion, biopsy, and PCR testing aid diagnosis, while combination chemotherapy and surgery are key treatments.

Area of Science:

  • Dermatology
  • Infectious Diseases
  • Microbiology

Background:

  • Cutaneous tuberculosis (TB) exhibits varied clinical presentations.
  • Skin TB can arise from direct inoculation, local spread, or hematogenous dissemination.
  • High index of suspicion is crucial due to diverse manifestations.

Purpose of the Study:

  • Classify cutaneous TB manifestations by infection source (exogenous, endogenous, hematogenous).
  • Correlate clinical appearance and histology with infection routes.
  • Clarify terminology and diagnostic approaches for cutaneous TB.

Main Methods:

  • Review and classification of clinical presentations based on infection source.
  • Histopathological examination of skin lesions.

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  • Application of ancillary diagnostic tools like PCR and monoclonal antibodies when needed.

    • Main Results:

    • Clinical presentations are categorized by exogenous, endogenous, and hematogenous spread.
    • Histopathology may show nonspecific inflammation, necessitating advanced tests.
    • PCR amplification significantly aids in identifying Mycobacterium tuberculosis in skin biopsies, especially with negative cultures.

    Conclusions:

    • Accurate diagnosis of cutaneous TB relies on recognizing varied presentations and utilizing appropriate diagnostic methods.
    • Combination chemotherapy is the mainstay treatment, particularly for disseminated or severe cases.
    • Surgical intervention can serve both diagnostic and therapeutic purposes in managing cutaneous TB.