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[Mediastinal carcinomas in young men without primary tumors. A chemosensitive entity?]
I Marin1, C Delaisements, J M Andrieu
1Clinique de Pneumo-Phtisiologie, Hôpital Laënnec, Paris.
Revue Des Maladies Respiratoires
|January 1, 1987
Summary
Complete remission was observed in 3 out of 99 patients with broncho-pulmonary cancer treated with Cisplatinum and Vindesine chemotherapy. This suggests chemotherapy can be beneficial for these rare mediastinal tumors, even without a known primary origin.
Area of Science:
- Oncology
- Medical Research
Background:
- Investigating treatment outcomes for rare broncho-pulmonary cancers.
- Evaluating chemotherapy efficacy in patients with mediastinal tumors of unknown primary origin.
Observation:
- Three out of 99 patients achieved complete remission.
- Patients presented with a characteristic tumor type, potentially of germ cell origin.
- Tumors showed tropism for the mediastinum.
Findings:
- Chemotherapy with Cisplatinum and Vindesine led to complete remission in a subset of patients.
- The observed remissions occurred in cases of "broncho-pulmonary" cancer without a specified primary tumor.
Implications:
- Complete remissions, though rare, support the use of chemotherapy for these specific cancers.
- Further research into the germ origin hypothesis may refine treatment strategies.
- Chemotherapy offers a potential therapeutic avenue for mediastinal tumors of unknown primary origin.