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Updated: Mar 7, 2026
A Novel Method: Super-selective Adrenal Venous Sampling
Published on: September 15, 2017
Preoperative adrenal biopsy does not affect overall survival in adrenocortical carcinoma
Paritosh Suman1, Natalie Calcatera2, Chi-Hsiung Wang3
1Department of Surgery, NorthShore University Health System, Baptist Health Medical Group, Evanston, IL, USA.
Background:
The impact of preoperative biopsy on overall survival (OS) in adrenocortical carcinoma (ACC) is unclear. We analyzed the National Cancer Data Base (NCDB) for factors associated with preoperative adrenal biopsy and its effect on OS in ACC.
Methods:
The NCDB was queried from 2003 to 2012 for M0 ACC. Patients with or without preoperative biopsy were compared for factors associated with an increased rate of biopsy. Survival analysis was performed after adjusting for patient and tumor-related variables.
Results:
There were 1782 patients with M0 ACC of whom 332 (19%) had a preoperative biopsy. Treatment outside academic cancer centers (OR 1.36, 95% CI 1.04-1.77, P = 0.023) and male gender (OR 1.45, 95% CI 1.11-1.88, P = 0.006) were associated with an increased rate of biopsy. In patients undergoing adrenalectomy with negative margins, biopsy failed to impact OS (log-rank P = 0.225, HR 1.20, 95% CI 0.84-1.72, P = 0.306).
Conclusions:
Preoperative adrenal biopsy continues to be performed for ACC with no added survival benefit. Adrenalectomy offers the best chance of survival in patients with ACC.
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