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Monitoring system for adverse events following immunization
H C Stetler1, J R Mullen, J P Brennan
1Division of Immunization, Centers for Disease Control, Atlanta, Georgia 30333.
Abstract:
The Monitoring System for Adverse Events Following Immunization (MSAEFI) has collected data from the public sector nationwide on adverse events occurring during the 4-week period following administration of vaccine. From 1979 to 1984, 6483 reports were received. Although rates of reporting have increased throughout the 6-year period, increases were larger for less serious events (209%) than for more serious events (53%). The MSAEFI data have been used to evaluate risk factors for adverse events following immunization, will continue to provide information on the safety of both current and future vaccines and may identify other factors that increase the risks of adverse events following immunization.
Insights
The Monitoring System for Adverse Events Following Immunization (MSAEFI) collected 6483 reports from 1979-1984. Reporting increased, with larger gains for less serious vaccine side effects than for serious ones.
Area of Science:
- Public Health
- Immunization Safety
- Pharmacovigilance
Background:
- Adverse events following immunization (AEFI) require robust monitoring.
- The Monitoring System for Adverse Events Following Immunization (MSAEFI) was established for nationwide data collection.
- Understanding AEFI reporting trends is crucial for vaccine safety surveillance.
Purpose of the Study:
- To analyze AEFI reporting trends from 1979 to 1984.
- To assess changes in reporting rates for serious versus less serious adverse events.
- To highlight the utility of MSAEFI data for evaluating immunization risks.
Main Methods:
- Data collection through the MSAEFI in the public sector.
- Analysis of 6483 AEFI reports received between 1979 and 1984.
- Comparison of reporting rate increases for different event severities.
Main Results:
- Overall increase in AEFI reporting rates during the study period.
- Significantly larger increases in reporting for less serious events (209%) compared to serious events (53%).
- Demonstrated utility of MSAEFI data for risk factor evaluation.
Conclusions:
- MSAEFI provides valuable data on vaccine safety.
- Reporting trends suggest increased awareness or reporting of less severe adverse events.
- Continued use of MSAEFI data is essential for monitoring current and future vaccine safety.