Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Dementia01:30

Dementia

633
Dementia is a collective term for cognitive disorders primarily affecting memory, thinking, and reasoning. It is not a specific disease but a syndrome, with Alzheimer's disease being the most common cause, accounting for approximately 60-80% of cases. Other types include vascular dementia, Lewy body dementia, and frontotemporal dementia. Dementia affects millions worldwide, particularly older adults, though it is not a normal part of aging.
The progression of dementia is generally gradual....
633
Alzheimer's Disease: Overview01:26

Alzheimer's Disease: Overview

1.9K
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
1.9K
Alzheimer's Disease: Treatment01:22

Alzheimer's Disease: Treatment

1.1K
Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
1.1K
Parkinson's Disease: Overview01:15

Parkinson's Disease: Overview

2.3K
Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
2.3K
Therapeutic Communication01:30

Therapeutic Communication

9.9K
Communication is a lifelong learning process. Through therapeutic communication, nurses can collect relevant assessment data, provide education and counseling, and interact during nursing interventions. Sending and receiving messages occur through verbal and nonverbal communication techniques and can happen separately or simultaneously.
Verbal communication depends on language or a prescribed way of using words so that people can share information effectively. The critical aspects of verbal...
9.9K
Parkinson's Disease: Treatment01:24

Parkinson's Disease: Treatment

1.3K
Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
1.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Corrigendum to "Spontaneous narrative production in focal neurodegenerative disease" [Neuropsychologia 97 (2015) 158-171].

Neuropsychologia·2018
Same author

Murine knockin model for progranulin-deficient frontotemporal dementia with nonsense-mediated mRNA decay.

Proceedings of the National Academy of Sciences of the United States of America·2018
Same author

Frontotemporal dementia.

Handbook of clinical neurology·2018
Same author

Increased subjective experience of non-target emotions in patients with frontotemporal dementia and Alzheimer's disease.

Current opinion in behavioral sciences·2018
Same author

Early vs late age at onset frontotemporal dementia and frontotemporal lobar degeneration.

Neurology·2018
Same author

The Longitudinal Trajectory of Default Mode Network Connectivity in Healthy Older Adults Varies As a Function of Age and Is Associated with Changes in Episodic Memory and Processing Speed.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2018

Related Experiment Video

Updated: Mar 7, 2026

Author Spotlight: Deciphering the Cognitive and Neural Mechanisms of Gesture in Communication
07:18

Author Spotlight: Deciphering the Cognitive and Neural Mechanisms of Gesture in Communication

Published on: January 26, 2024

1.4K

Observing conversational laughter in frontotemporal dementia.

Peter S Pressman1,2,3, Michaela Simpson3, Kelly Gola2

  • 1Rocky Mountain Alzheimer's Disease Center, Department of Neurology, University of Colorado, Denver, Colorado, USA ppressman@memory.ucsf.edu peter.pressman@ucdenver.edu.

Journal of Neurology, Neurosurgery, and Psychiatry
|February 26, 2017
PubMed
Summary

Individuals with behavioral variant frontotemporal dementia (bvFTD) and other dementia types laughed less during conversations. Laughter patterns may aid in dementia diagnosis.

More Related Videos

Examining the Characteristics of Episodic Memory using Event-related Potentials in Patients with Alzheimer's Disease
11:01

Examining the Characteristics of Episodic Memory using Event-related Potentials in Patients with Alzheimer's Disease

Published on: August 30, 2011

14.1K
Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains
12:28

Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains

Published on: June 3, 2020

18.4K

Related Experiment Videos

Last Updated: Mar 7, 2026

Author Spotlight: Deciphering the Cognitive and Neural Mechanisms of Gesture in Communication
07:18

Author Spotlight: Deciphering the Cognitive and Neural Mechanisms of Gesture in Communication

Published on: January 26, 2024

1.4K
Examining the Characteristics of Episodic Memory using Event-related Potentials in Patients with Alzheimer's Disease
11:01

Examining the Characteristics of Episodic Memory using Event-related Potentials in Patients with Alzheimer's Disease

Published on: August 30, 2011

14.1K
Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains
12:28

Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains

Published on: June 3, 2020

18.4K

Area of Science:

  • Neurology
  • Psychology
  • Linguistics

Background:

  • Dementia affects communication and social interaction.
  • Laughter patterns may differ across dementia subtypes.
  • Observational studies can reveal subtle communication changes.

Purpose of the Study:

  • To investigate laughter patterns in patients with various dementia types during conversations.
  • To compare laughter frequency and context in behavioral variant frontotemporal dementia (bvFTD), right temporal variant frontotemporal dementia (rtFTD), semantic variant primary progressive aphasia (svPPA), non-fluent variant primary progressive aphasia (nfvPPA), and early onset Alzheimer's disease (eoAD) compared to controls.
  • To explore the potential of laughter as a diagnostic marker for dementia.

Main Methods:

  • An observational study was conducted with patients diagnosed with specific dementia subtypes and healthy controls.
  • Participants engaged in semi-naturalistic conversations with a companion.
  • Laughter events were identified and categorized into 'self' (own vocalization) and 'partner' (partner's vocalization) contexts using audio recordings and automated algorithms.

Main Results:

  • Individuals with bvFTD, early onset Alzheimer's disease (eoAD), and rtFTD exhibited reduced laughter in both self and partner contexts compared to other groups.
  • bvFTD patients laughed less in response to their own speech relative to healthy controls.
  • nfvPPA patients showed increased laughter in the partner context compared to healthy controls.

Conclusions:

  • Laughter patterns, specifically in response to one's own or a partner's speech, may serve as a clinically valuable indicator in dementia diagnosis.
  • Differential laughter responses across dementia subtypes highlight the potential for nuanced diagnostic tools.
  • Further research into non-verbal communication cues in dementia is warranted.