Competition between low and high pathogenicity avian influenza in a two-patch system
1Department of Mathematics, University of Florida, Gainesville, FL 32611, United States.
Mathematical Biosciences
|February 27, 2017
Summary
Highly pathogenic avian influenza (HPAI) outbreaks are increasing. This study models how bird migration between live poultry markets affects the spread of HPAI versus low pathogenic avian influenza (LPAI).
Area of Science:
- Epidemiology
- Mathematical Biology
- Veterinary Science
Background:
- Avian influenza epidemiology has transformed, with rising outbreaks of highly pathogenic avian influenza (HPAI).
- Live poultry markets are significant hubs for avian influenza transmission.
- Increased HPAI outbreaks lead to higher infection rates and control costs.
Purpose of the Study:
- To model the competitive dynamics between low pathogenic avian influenza (LPAI) and HPAI strains.
- To investigate the impact of migration between live poultry markets on disease spread.
- To analyze the stability of disease equilibria and determine critical thresholds (R0).
Main Methods:
- Development of a two-patch mathematical model representing live poultry markets.
- Utilizing a system of differential equations to analyze disease dynamics.
- Assessment of the existence and stability of LPAI and HPAI equilibria.
Main Results:
- Migration generally increases the prevalence of HPAI in poultry populations.
- Migration promotes the coexistence of LPAI and HPAI strains in Patch 2.
- The region of coexistence in Patch 1 fluctuates with active inter-patch migration.
Conclusions:
- Migration between live poultry markets significantly influences avian influenza strain competition.
- HPAI prevalence is exacerbated by bidirectional migration.
- Understanding migration dynamics is crucial for controlling avian influenza spread in live poultry markets.
More Related Videos
Related Concept Videos
00:57Viral Recombination
25.4K
Cells are sometimes infected by more than one virus at once. When two viruses disassemble to expose their genomes for replication in the same cell, similar regions of their genomes can pair together and exchange sequences in a process called recombination. Alternatively, viruses with segmented genomes can swap segments in a process called reassortment.
25.4K
02:28Leaky Scanning
5.8K
During most eukaryotic translation processes, the small 40S ribosome subunit scans an mRNA from its 5' end until it encounters the first start AUG codon. The large 60S ribosomal subunit then joins the smaller one to initiate protein synthesis. The location of the translation initiation is largely determined by the nucleotides near the start codon as there may be multiple translation initiation sites present on the mRNA. Marilyn Kozak discovered that the sequence RCCAUGG (where R...
5.8K