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Updated: Mar 7, 2026
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Measurement of Tissue Oxygenation Using Near-Infrared Spectroscopy in Patients Undergoing Hemodialysis
Published on: October 2, 2020
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Native T1 mapping: inter-study, inter-observer and inter-center reproducibility in hemodialysis patients
Matthew P M Graham-Brown1,2,3, Elaine Rutherford4,5, E Levelt6
1John Walls Renal Unit, University Hospitals Leicester NHS Trust, Leicester, UK. mpmgb1@le.ac.uk.
Summary
Native T1 mapping using cardiovascular magnetic resonance (CMR) is reproducible in hemodialysis patients and unaffected by fluid status changes. This technique shows potential as an imaging biomarker for myocardial fibrosis in end-stage renal disease.
Area of Science:
- Cardiovascular Magnetic Resonance
- Renal Disease Imaging
- Biomarker Development
Background:
- Native T1 mapping is a cardiovascular magnetic resonance (CMR) technique associated with fibrosis and strain in hemodialysis (HD) patients.
- Reproducibility of T1 mapping in HD patients, who experience fluid status fluctuations, is not well-established.
- Accurate myocardial fibrosis quantification in HD patients may offer prognostic value.
Purpose of the Study:
- Assess the reproducibility of native T1 mapping in HD patients.
- Evaluate the impact of fluid status variations on native T1 values.
- Determine the potential of native T1 mapping as a biomarker for myocardial fibrosis in end-stage renal disease.
Main Methods:
- Utilized 3 Tesla CMR to assess inter-study, inter-observer, and intra-observer reproducibility of native T1 mapping.
- Examined inter-study reproducibility of left ventricular (LV) structure and function.
- Compared native T1 mapping and phantom analyses between two centers.
- Investigated the relationship between fluid status markers and native T1 values in HD patients.
Main Results:
- Native T1 mapping demonstrated excellent reproducibility with low coefficients of variation (CoV) for inter-study (0.7%), inter-observer (0.3%), and intra-observer (0.4%) variability.
- Left ventricular structure and function parameters showed good inter-study reproducibility (CoV: 1-5.6%).
- Inter-center analyses of native T1 mapping were excellent (CoV: 0.8-1.2%), with comparable phantom results across different scanners.
- Changes in body weight (fluid status) did not correlate with changes in native T1 values, indicating T1 mapping is unaffected by observed fluid status fluctuations.
Conclusions:
- Myocardial native T1 values are reproducible in hemodialysis patients.
- Native T1 mapping is not significantly affected by fluid status changes within the observed range.
- Native T1 mapping represents a promising imaging biomarker for assessing myocardial fibrosis in patients with end-stage renal disease.
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