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Intestinal barrier integrity and function in infants with cholestasis.

Nagla H Abu Faddan1, Tahra M K Sherif2, Omnia A Mohammed2

  • 1Department of Pediatrics, Faculty of Medicine, Assiut University, Assiut, Egypt.

Intestinal Research
|February 28, 2017
PubMed
Summary

Infants with cholestasis show impaired intestinal barrier integrity, indicated by elevated intestinal fatty acid binding protein (I-FABP) and ileal bile acid binding protein (I-BABP) levels. Gut wall permeability, however, remained unchanged in these infants.

Keywords:
CholestasisInfantIntestinal barrier

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Area of Science:

  • Pediatric Gastroenterology
  • Neonatal Research
  • Intestinal Barrier Function

Background:

  • The intestinal barrier is crucial for protecting the body from harmful compounds.
  • Cholestasis and bile absence can compromise intestinal barrier function.
  • Infant cholestasis may lead to impaired gut barrier integrity.

Purpose of the Study:

  • To assess gut barrier integrity in infants with cholestasis.
  • To evaluate intestinal fatty acid binding protein (I-FABP) and ileal bile acid binding protein (I-BABP) as markers of epithelial damage.
  • To measure plasma D-lactate as a marker of gut wall permeability.

Main Methods:

  • A case-control study involving 53 infants with cholestasis and 29 controls.
  • Serum levels of I-FABP, I-BABP, and D-lactate were measured.
  • Comparison of marker levels between cholestatic infants and healthy controls.

Main Results:

  • Infants with neonatal hepatitis and biliary atresia had significantly higher I-FABP and I-BABP levels than controls.
  • No significant differences in serum D-lactate levels were observed between groups.
  • No correlations were found between I-FABP, I-BABP, or D-lactate and bilirubin levels.

Conclusions:

  • Intestinal epithelial barrier integrity is compromised in infants with cholestasis.
  • Further research is needed to understand the clinical implications for infant management.
  • The link between physical barrier damage and functional failure requires further investigation.