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Longitudinal Morphological and Physiological Monitoring of Three-dimensional Tumor Spheroids Using Optical Coherence Tomography
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Cubic meter volume optical coherence tomography.

Zhao Wang1, Benjamin Potsaid2, Long Chen3

  • 1Department of Electrical Engineering & Computer Science and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.

Optica
|February 28, 2017
PubMed
Summary
This summary is machine-generated.

We developed a new 3D Optical Coherence Tomography (OCT) system capable of imaging meter-scale volumes with micrometer resolution. This breakthrough expands the imaging range of high-speed OCT for diverse applications.

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Area of Science:

  • Biomedical Imaging
  • Optical Engineering
  • Photonics

Background:

  • Optical Coherence Tomography (OCT) offers high-resolution 3D imaging.
  • Current high-speed OCT systems have limited imaging range.

Purpose of the Study:

  • To extend the imaging range of high-speed 3D OCT to cubic meter volumes.
  • To demonstrate meter-range OCT capabilities for macroscopic imaging.

Main Methods:

  • Utilized a long coherence length, 1310 nm vertical-cavity surface-emitting laser.
  • Employed silicon photonic integrated circuit dual-quadrature receiver technology.
  • Implemented enhanced signal processing techniques.

Main Results:

  • Achieved 15 µm depth resolution for tomographic imaging.
  • Demonstrated imaging over a 1.5 m range at a 100 kHz axial scan rate.
  • Successfully imaged macroscopic objects including a mannequin, bicycle, gauge blocks, and skull/brain model.

Conclusions:

  • High-bandwidth, meter-range OCT significantly expands imaging capabilities.
  • This technology promises broad applications in biomedical, scientific, and industrial fields.