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Single-photon avalanche diode imaging sensor for subsurface fluorescence LiDAR.

Petr Bruza1, Arthur Petusseau1, Arin Ulku2

  • 1Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire 03766, USA.

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Summary
This summary is machine-generated.

This study presents subsurface fluorescence LiDAR, a novel technique using a large single-photon avalanche diode array to accurately detect fluorescent molecules deep within scattering materials like tissue.

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Area of Science:

  • Biomedical Optics
  • Photonics
  • Fluorescence Imaging

Background:

  • Subsurface imaging in scattering media is challenging.
  • Accurate localization and quantification of fluorescent molecules are crucial for diagnostics.
  • Existing techniques have limitations in depth accuracy and resolution.

Purpose of the Study:

  • To develop a subsurface fluorescence Light Detection and Ranging (LiDAR) system.
  • To achieve submillimeter depth accuracy for molecular detection.
  • To enable quantification of fluorescent molecule concentration in scattering tissues.

Main Methods:

  • Utilized a large-format single-photon avalanche diode array.
  • Implemented a fluorescence LiDAR system for subsurface measurements.
  • Developed algorithms for signal processing and depth localization.

Main Results:

  • Demonstrated successful subsurface fluorescence detection.
  • Achieved submillimeter depth accuracy in heavily scattering media.
  • Successfully localized and quantified fluorescent molecule concentrations.

Conclusions:

  • The developed subsurface fluorescence LiDAR system offers high depth accuracy.
  • This technology has potential applications in biomedical imaging and diagnostics.
  • The single-photon avalanche diode array enables precise detection in challenging environments.