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Toward Hydrogen Sulfide Based Therapeutics: Critical Drug Delivery and Developability Issues
Yueqin Zheng1, Bingchen Yu1, Ladie Kimberly De La Cruz1
1Department of Chemistry, Georgia State University, Atlanta, Georgia.
Medicinal Research Reviews
|February 28, 2017
Summary
Hydrogen sulfide (H₂S) is a gasotransmitter with therapeutic potential. This study reviews drug delivery strategies for H₂S, evaluating their use as research tools and therapeutic agents.
Area of Science:
- Biochemistry
- Pharmacology
- Physiology
Background:
- Hydrogen sulfide (H₂S) is a key gasotransmitter alongside nitric oxide (NO) and carbon monoxide (CO).
- H₂S exhibits diverse therapeutic effects, including cardioprotection, antioxidant properties, neurotransmission modulation, and vasodilation.
- Effective drug delivery remains a significant hurdle for H₂S-based therapeutics.
Purpose of the Study:
- To review and assess various drug delivery strategies for hydrogen sulfide (H₂S).
- To evaluate the suitability of these strategies as research tools.
- To determine the potential developability of H₂S delivery systems as therapeutic agents.
Main Methods:
- Literature review of existing H₂S drug delivery systems.
- Analysis of delivery strategies based on research utility.
- Assessment of developability for therapeutic applications.
Main Results:
- Various drug delivery strategies for H₂S have been explored.
- The utility of these strategies as research tools varies.
- Developability as therapeutic agents requires further investigation for many strategies.
Conclusions:
- Optimizing H₂S drug delivery is crucial for its therapeutic advancement.
- Careful consideration of delivery methods is needed for both research and clinical applications.
- Further research into novel delivery systems is warranted to overcome current challenges.
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