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Related Concept Videos

Circadian Rhythms and Gene Regulation02:19

Circadian Rhythms and Gene Regulation

The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent years,...
Circadian Rhythms and Gene Regulation02:19

Circadian Rhythms and Gene Regulation

The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent years,...
Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response01:15

Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response

Circadian rhythms are cyclic changes that are crucial in plasma drug concentrations. Various standard circadian parameters, including core body temperature, heart rate, and other cardiovascular factors, directly impact disease states and the therapeutic response to drug therapy.
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
Inhibition of Cdk Activity02:34

Inhibition of Cdk Activity

The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...
Inhibition of CDK Activity02:34

Inhibition of CDK Activity

The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...
Management of Insomnia01:19

Management of Insomnia

The sleep cycle, an integral part of human health, consists of several stages with distinct characteristics and functions. It begins with a transition from wakefulness to sleep, known as the light sleep phase, followed by the restorative deep sleep phase, essential for physical recovery and growth. The cycle concludes with the Rapid Eye Movement (REM) phase, characterized by high brain activity and vivid dreaming. Insomnia, a prevalent sleep disorder, involves difficulty falling asleep, staying...

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Updated: Jun 16, 2026

In Vitro Bioluminescence Assay to Characterize Circadian Rhythm in Mammary Epithelial Cells
11:56

In Vitro Bioluminescence Assay to Characterize Circadian Rhythm in Mammary Epithelial Cells

Published on: September 28, 2017

Small-Molecule Kinase Inhibitors Modulating Circadian Rhythms.

Irene Castellino1,2, Manuela Bartolini2, Rudolf Andrys1

  • 1Department of Chemistry, Faculty of Science, University of Hradec Kralove, Hradec Kralove, Czech Republic.

Medicinal Research Reviews
|June 15, 2026
PubMed
Summary
This summary is machine-generated.

Kinase inhibitors show promise for treating circadian clock disorders by targeting phosphorylation in the cellular feedback loop. Further research is needed to bridge the gap between lab results and effective in vivo treatments.

Keywords:
circadian clockcircadian rhythminhibitorkinase

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Last Updated: Jun 16, 2026

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Flexible Measurement of Bioluminescent Reporters Using an Automated Longitudinal Luciferase Imaging Gas- and Temperature-optimized Recorder (ALLIGATOR)
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Area of Science:

  • Biochemistry
  • Chronobiology
  • Pharmacology

Background:

  • The circadian clock regulates vital physiological processes via a transcriptional-translational feedback loop.
  • Phosphorylation is critical for maintaining circadian rhythm accuracy within cells.
  • Dysregulation of the circadian clock is linked to various diseases.

Purpose of the Study:

  • To review current kinase inhibitors affecting the mammalian circadian clock.
  • To identify promising therapeutic targets and limitations of existing inhibitors.
  • To guide future research for novel treatments of circadian-related disorders.

Main Methods:

  • Literature review of kinase inhibitors and their effects on the circadian clock.
  • Analysis of phosphorylation's role in circadian rhythm regulation.
  • Evaluation of in vitro activity versus in vivo effectiveness.

Main Results:

  • Kinase inhibitors are potential modulators of the circadian clock.
  • Significant discrepancies exist between in vitro and in vivo efficacy of inhibitors.
  • Specific targets and limitations of current compounds are highlighted.

Conclusions:

  • Kinase inhibitors offer a promising avenue for treating circadian rhythm disorders.
  • Rigorous in vivo validation is essential to translate therapeutic potential into clinical applications.
  • Further development is needed to overcome limitations and ensure effective treatments.