Related Experiment Video
Updated: Jan 13, 2026
08:48
Development of a Backbone Cyclic Peptide Library as Potential Antiparasitic Therapeutics Using Microwave Irradiation
Published on: January 26, 2016
12.3K
Human Cyclophilins-An Emerging Class of Drug Targets
Katarina Jurkova1, Hana Navratilova1, Kamil Musilek1
1Department of Chemistry, Faculty of Science, University of Hradec Kralove, Hradec Kralove, Czech Republic.
Medicinal Research Reviews
|October 29, 2025
Summary
Cyclophilins are enzymes involved in many biological processes. Targeting these enzymes with small-molecule inhibitors shows potential for treating diseases like cancer and Alzheimer's.
Area of Science:
- Biochemistry
- Molecular Biology
- Pharmacology
Background:
- Cyclophilins are enzymes catalyzing peptidyl-prolyl isomerase activity.
- Seventeen human cyclophilin isoforms are known, each involved in distinct biological functions.
- These enzymes are implicated in various diseases, including viral infections, neurodegenerative disorders, cardiovascular conditions, and cancer.
Purpose of the Study:
- To review the structural features of human cyclophilin isoforms.
- To explore the roles of cyclophilins in health and disease.
- To discuss the therapeutic potential of cyclophilin inhibitors.
Main Methods:
- Literature review focusing on cyclophilin structure, function, and disease association.
- Analysis of current research on small-molecule cyclophilin inhibitors.
- Examination of therapeutic strategies targeting cyclophilins.
Main Results:
- Detailed descriptions of individual cyclophilin isoform structures and functions.
- Elucidation of cyclophilin involvement in viral infections, Alzheimer's, Parkinson's, cardiovascular diseases, and cancer.
- Identification of selective small-molecule inhibitors as promising therapeutic agents.
Conclusions:
- Cyclophilins are crucial in diverse biological processes and disease pathogenesis.
- Targeting specific cyclophilin isoforms with selective inhibitors offers a promising avenue for novel therapeutics.
- Further research into cyclophilin inhibition could lead to treatments for numerous human diseases.
Keywords:
cyclophilin (Cyp)cyclosporine A (CsA)drug targetenzyme inhibitionpeptidyl‐prolyl cis‐trans isomerase (PPIase)More Related Videos
10:20Method for Identifying Small Molecule Inhibitors of the Protein-protein Interaction Between HCN1 and TRIP8b
Published on: November 11, 2016
8.9K
07:41A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators
Published on: February 20, 2018
9.4K
Related Concept Videos
01:26Targets for Drug Action: Overview
10.0K
Drugs target macromolecules to modify ongoing cellular processes. Primary drug targets include receptors, ion channels, transporters, and enzymes.
Receptors are either membrane-spanning or intracellular proteins, which upon binding a ligand, get activated and transmit the signal downstream to elicit a response. Drugs bind receptors, either mimicking the action of endogenous ligands or blocking the receptor activity to bring about a modified response. Nearly 35% of approved drugs target the G...
Receptors are either membrane-spanning or intracellular proteins, which upon binding a ligand, get activated and transmit the signal downstream to elicit a response. Drugs bind receptors, either mimicking the action of endogenous ligands or blocking the receptor activity to bring about a modified response. Nearly 35% of approved drugs target the G...
10.0K
01:26Drug Discovery: Overview
10.9K
Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...
10.9K
01:27Transducer Mechanism: Enzyme-Linked Receptors
3.8K
Enzyme-linked receptors are cell-surface receptors acting as an enzyme or associating with an enzyme intracellularly. They make excellent drug targets. Drugs can bind to the extracellular ligand-binding domain or directly affect their enzymatic domain and alter their activity.
Major types that are helpful drug targets include:
Major types that are helpful drug targets include:
3.8K
01:24Principles of Drug Action
8.0K
Drugs are chemical substances that modify biological responses by interacting with macromolecular targets such as receptors, ion channels, transporters, and enzymes. Pharmacodynamics describes the course of action of drugs leading to the physiological effect at a specific site in the body.
Drugs can be agonists or antagonists. Like the endogenous ligands, agonists always bind and activate the target to produce a cellular response. Agonist binding induces a conformational change which in turn...
Drugs can be agonists or antagonists. Like the endogenous ligands, agonists always bind and activate the target to produce a cellular response. Agonist binding induces a conformational change which in turn...
8.0K
00:55DNA Helicases
23.8K
DNA unwinding helicase enzymes are a type of motor protein. Motor proteins can translocate along filaments or polymers using energy generated from ATP hydrolysis. Helicases are involved in all the important cellular processes where DNA unwinding is required, such as DNA replication, repair, recombination, and transcription. They are present in all living organisms, but vary in their structure, function, and mechanism of action. For example, in prokaryotes, DnaB helicase binds and translocates...
23.8K
02:39Positive Regulator Molecules
6.5K
Mitotic cell division results in daughter cells that exactly resemble the parent cell. However, errors in the DNA replication or distribution of genetic material may lead to genetic mutations that may be passed down to every new cell formed from the resulting abnormal cell. Propagation of such mutant cells is restricted through checkpoint mechanisms present at different stages of the cell cycle. These checkpoints involve regulator molecules that either promote or demote cell cycle events.
6.5K