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Cardiac myosin and autoimmune myocarditis
N R Rose1, K W Beisel, A Herskowitz
1Department of Immunology and Infectious Diseases, Johns Hopkins Medical Institutions, Baltimore, Maryland 21205.
Ciba Foundation Symposium
|January 1, 1987
Summary
Coxsackievirus B3 infection can cause myocarditis, a heart inflammation. Genetic predisposition and cardiac myosin autoantibodies play a role in developing this autoimmune heart disease.
Area of Science:
- Virology
- Immunology
- Cardiology
Background:
- Coxsackievirus B3 (CB3) infection is a known cause of human myocarditis.
- Heart-reactive antibodies suggest autoimmunity in later disease stages.
- Myocarditis is a rare complication, implying genetic susceptibility.