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[Viral failure in infants perinatally infected with HIV: A double punishment]

N Trocmé1, M-F Courcoux1, M-D Tabone1

  • 1Service d'hématologie et oncologie pédiatrique, hôpital d'enfants A.-Trousseau, AP-HP, 26, avenue du Dr-Arnold-Netter-Paris, 72012 Paris, France.

Archives De Pediatrie : Organe Officiel De La Societe Francaise De Pediatrie
|March 1, 2017
PubMed

Insights

Severe maternal psychological disorders in HIV-positive mothers are linked to infant viral failure despite effective prevention of mother-to-child transmission (PMTCT) strategies. This highlights the need for integrated mental health support in PMTCT programs.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Psychiatry

Background:

  • Preventing mother-to-child transmission (PMTCT) of HIV is highly effective, yet failures warrant investigation, particularly concerning infant viral failure.
  • Infants diagnosed with HIV before one year of age are at increased risk for viral failure.
  • Maternal psychological factors may influence viral control in HIV-infected infants.

Purpose of the Study:

  • To analyze factors associated with viral failure in infants diagnosed with HIV before one year of age.
  • To investigate the role of the child's environment and maternal psychological factors in infant viral failure.

Main Methods:

  • Retrospective study of HIV-infected infants diagnosed before age one in France (2003-2013).
  • Comparison of infants with viral success versus those with viral failure.
  • Analysis of medical, psychological, and social data from patient files.

Main Results:

  • Of 14 infants studied, seven achieved viral success and seven did not.
  • Mothers of infants with viral failure had severe psychological disorders.
  • Maternal psychological issues led to treatment adherence problems and difficulties administering infant medication.

Conclusions:

  • Severe maternal psychological or psychiatric conditions are significant risk factors for residual mother-to-child transmission of HIV.
  • These maternal conditions also contribute to viral failure in infants, even in high-resource settings.
  • Integrated maternal mental health care is crucial for successful PMTCT and infant outcomes.
Abstract

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