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Acute Hemorrhagic Edema of Infancy after Coronavirus Infection with Recurrent Rash.

Hannah Chesser¹, Jeffrey M Chambliss², Eric Zwemer¹

¹Department of Pediatrics, University of North Carolina, Chapel Hill, NC, USA.

Case Reports in Pediatrics

|March 1, 2017

Summary

Acute hemorrhagic edema of infancy (AHEI) is a benign vasculitis causing purpura in children. This case highlights AHEI triggered by coronavirus, with a recurrence observed.

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Area of Science:

Pediatric Dermatology
Pediatric Rheumatology
Pediatric Infectious Diseases

Background:

Acute hemorrhagic edema of infancy (AHEI) is a rare, benign small-vessel vasculitis.
It typically affects infants and young children, presenting with characteristic purpuric lesions.
AHEI is often self-limiting with an excellent prognosis.

Observation:

A previously healthy 8-month-old female presented with progressive purpura, low-grade fevers, and extremity swelling.
The purpuric rash had a nondependent distribution, differing from typical presentations.
Extensive workup was required to differentiate AHEI from other serious conditions.

Findings:

The clinical presentation and subsequent diagnosis confirmed AHEI.
Coronavirus was identified as the probable triggering pathogen.
The patient experienced a recurrence of symptoms several weeks after the initial presentation.

Implications:

This case underscores the importance of considering AHEI in infants with purpuric rashes and fever.
It highlights a potential association between coronavirus infection and AHEI.
Recognizing AHEI is crucial to avoid unnecessary investigations and treatments for a benign condition.