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Updated: Mar 7, 2026
Author Spotlight: Advancing Tendon Tissue Engineering with 3D Organoid Models
Published on: June 21, 2024
Reconstruction of Ligament and Tendon Defects Using Cell Technologies
R K Chailakhyan1, A B Shekhter2, S V Ivannikov2
1N. F. Gamaleya Research Centre of Epidemiology and Microbiology, Ministry of Health of the Russian Federation, Moscow, Russia. rubenchail@yandex.ru.
Abstract:
We studied the possibility of restoring the integrity of the Achilles tendon in rabbits using autologous multipotent stromal cells. Collagen or gelatin sponges populated with cells were placed in a resorbable Vicryl mesh tube and this tissue-engineered construct was introduced into a defect of the middle part of the Achilles tendon. In 4 months, histological analysis showed complete regeneration of the tendon with the formation of parallel collagen fibers, spindle-shaped tenocytes, and newly formed vessels.
