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Using Thermogenic Beige Cells to Identify Biologically Active Small Molecules and Peptides
1Department of Biochemistry, Center for Drug Discovery, and Translational Obesity Research Center, Virginia Tech, 340 West Campus Dr., 105 Engel Hall,, Blacksburg, VA, 24061, USA.
Methods in Molecular Biology (Clifton, N.J.)
|March 1, 2017
Summary
This chapter details screening methods using thermogenic beige cells to discover new compounds and peptides. These approaches aim to identify novel activators of adipocyte thermogenesis for potential anti-obesity therapeutics.
Area of Science:
- Chemical Biology
- Cellular Biology
- Metabolic Research
Background:
- Molecular libraries in cell-based screenings facilitate gene discovery.
- Small molecules and protein biologics can reveal novel cellular mechanisms.
- Advances in thermogenic adipocyte research offer anti-obesity therapeutic potential.
Purpose of the Study:
- To describe screening methods utilizing thermogenic beige cells.
- To identify novel compounds and peptides that activate adipocyte thermogenesis.
Main Methods:
- Utilizing molecular libraries for chemical biology screenings.
- Employing cell-based assays with thermogenic beige cells.
- Screening small molecules and protein biologics.
Main Results:
- Identification of novel compounds activating adipocyte thermogenesis.
- Discovery of peptides that enhance thermogenic processes.
Conclusions:
- Screening thermogenic beige cells is a viable strategy for discovering anti-obesity therapeutics.
- This approach can uncover novel mechanisms in cellular energy expenditure.
