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The Prevalence of Marfan Syndrome in Korea

Shin Yi Jang1, Su Ra Seo2, Seung Woo Park1

  • 1Division of Cardiology, Department of Medicine, Heart Vascular Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Journal of Korean Medical Science
|March 1, 2017
PubMed

Insights

The prevalence of Marfan syndrome (MFS) in Korean adults increased from 0.90 to 2.27 per 100,000 people between 2006 and 2013. This rise was particularly notable in adolescent males and females.

Area of Science:

  • Genetics and Hereditary Diseases
  • Epidemiology
  • Public Health

Background:

  • Marfan syndrome (MFS) is a rare genetic disorder affecting connective tissue.
  • Accurate prevalence data is crucial for understanding disease burden and healthcare needs.
  • Previous MFS prevalence studies in Korea are limited, necessitating updated epidemiological assessment.

Purpose of the Study:

  • To determine the age-standardized prevalence of Marfan syndrome (MFS) in the adult Korean population.
  • To analyze trends in MFS prevalence from 2006 to 2013.
  • To identify demographic variations in MFS prevalence within specific age and sex groups.

Main Methods:

  • Utilized data from the Korean National Health Insurance Service (2006-2013).
  • Identified MFS cases using the ICD-10 code Q87.4 for primary diagnoses.
  • Calculated age-standardized prevalence rates based on the 2010 Korean population.

Main Results:

  • The overall age-standardized prevalence of MFS in Korean adults was 0.90 per 100,000 in 2006, rising to 2.27 per 100,000 in 2013.
  • In 2013, MFS prevalence was 2.61 per 100,000 overall for males and 4.32 per 100,000 for males aged 15-19.
  • In 2013, MFS prevalence was 1.92 per 100,000 overall for females and 3.02 per 100,000 for females aged 10-14.

Conclusions:

  • The age-standardized prevalence of Marfan syndrome in Korean adults significantly increased between 2006 and 2013.
  • Adolescent males (15-19 years) and young females (10-14 years) showed a particularly pronounced increase in MFS prevalence.
  • These findings highlight the need for continued surveillance and potentially targeted screening for MFS in the Korean population.
Keywords:
Marfan SyndromePrevalenceRepublic of Korea

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