Related Experiment Video

Updated: Mar 7, 2026

Probiotic Studies in Neonatal Mice Using Gavage
10:36

Probiotic Studies in Neonatal Mice Using Gavage

Published on: January 27, 2019

21.0K

Bifidobacterium bifidum OLB6378 Simultaneously Enhances Systemic and Mucosal Humoral Immunity in Low Birth Weight

Katsunori Tanaka1, Takamitsu Tsukahara2, Takahide Yanagi3

  • 1Department of Pediatrics, Shiga University of Medical Science, Seta Tsukinowa-cho, Otsu, Shiga 520-2192, Japan. tanakatsu0124@gmail.com.

Nutrients
|March 2, 2017
PubMed

Insights

Supplementation with Bifidobacterium bifidum OLB6378 enhanced infant humoral immunity. Non-live OLB6378 showed a more pronounced effect on immunoglobulin levels in low birth weight infants.

Area of Science:

  • Immunology
  • Microbiology
  • Neonatal Health

Background:

  • Probiotic supplementation is explored for enhancing humoral immunity.
  • Bifidobacterium bifidum OLB6378 (OLB6378) has been linked to reduced late-onset sepsis in infants.

Purpose of the Study:

  • To determine the effect of live OLB6378 on infant humoral immunity.
  • To investigate if non-live OLB6378 administration yields similar immune-enhancing effects.

Main Methods:

  • A non-randomized study involving low birth weight (LBW) infants (1500-2500 g).
  • Three groups: no intervention (N), live OLB6378 (L), and non-live OLB6378 (H).
  • Intervention from within 48 hours of birth to six months of age.

Main Results:

  • Group L showed significantly higher serum immunoglobulin G (IgG) levels compared to Group N.
  • Group H exhibited significantly higher serum IgG and intestinal secretory immunoglobulin A (SIgA) levels than Group N.
  • No significant differences in mortality or morbidity were observed between groups.

Conclusions:

  • OLB6378 administration in LBW infants enhances humoral immunity.
  • Non-live OLB6378 demonstrated a more significant impact on immune markers compared to live bacteria.
  • Non-live OLB6378 may be a more effective and practical option for immune enhancement in infant nutrition.

Keywords:
heat-treatedhumoral immunitynon-live bacteriaprobioticssepsisserum IgGstool secretory IgA

More Related Videos

Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels05:31

Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels

Published on: August 7, 2017

11.1K
Individualized Reconstitution of Human Milk Microbiota: A Feasible Approach in Real-World Settings04:16

Individualized Reconstitution of Human Milk Microbiota: A Feasible Approach in Real-World Settings

Published on: February 7, 2025

967

Related Concept Videos

Development of Immunocompetence01:22

Development of Immunocompetence

The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
1.1K
Anatomy of the Intestines01:23

Anatomy of the Intestines

Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
89.0K
Bacterial Flora of the Large Intestine01:29

Bacterial Flora of the Large Intestine

The gut microbiome is formed by a vast and diverse community of bacteria that colonizes our large intestine. These bacteria start residing in the gut from birth and continue diversifying throughout life, influenced by factors such as diet, lifestyle, and stress. The gut bacterial community also includes bacteria from food and those that enter the colon through the anus.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
1.8K
Transcytosis of IgG01:15

Transcytosis of IgG

Transcytosis is the process in which molecules are internalized by endocytosis, transported across the cell, and released through exocytosis from the opposite end of the cell. Molecules such as insulin, immunoglobulins, and certain nutrients are transferred through the recycling endosomes by recycling and transcytosis.
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...
4.4K
Humoral Immune Responses01:36

Humoral Immune Responses

Overview
85.0K
Mucosal Barrier of the Stomach01:25

Mucosal Barrier of the Stomach

The gastric glands contain parietal cells that secrete hydrochloric acid (HCl) for digestion. The cells secrete HCl because it is highly corrosive and essential for breaking down food. To achieve this, they secrete hydrogen and chloride ions into the lumen of the gastric glands, which combine to form HCl.
Within parietal cells, carbonic acid is first formed through the reaction of water and carbon dioxide. The dissociation of carbonic acid releases bicarbonate and hydrogen ions. The bicarbonate...
2.6K