Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Equilibrium and Balance01:15

Equilibrium and Balance

7.5K
The inner ear assumes dual functionalities of auditory perception and equilibrium maintenance. The vestibule is the organ responsible for balance. This organ contains mechanoreceptors, specifically hair cells, endowed with stereocilia, which aid in deciphering information regarding the position and motion of our heads. Two intrinsic components, the utricle and saccule, help perceive head position, while the semicircular canals track head movement. Neurological messages initiated in the...
7.5K
Pathophysiology of Vomiting01:22

Pathophysiology of Vomiting

3.6K
Vomiting is a complex physiological response to expel harmful or irritating substances from the body. It's a defensive mechanism triggered by stimuli like poisons, microbial toxins, cytotoxic drugs, and mechanical abdominal distension. The process is centrally coordinated by the vomiting (or emetic) center located in the medulla of the brainstem. This area, rich in muscarinic M1, histamine H1, neurokinin 1 (NK1), and serotonin 5-HT3 receptors, coordinates the act of vomiting through...
3.6K
The Vestibular System01:29

The Vestibular System

44.5K
The vestibular system is a set of inner ear structures that provide a sense of balance and spatial orientation. This system is comprised of structures within the labyrinth of the inner ear, including the cochlea and two otolith organs—the utricle and saccule. The labyrinth also contains three semicircular canals—superior, posterior, and horizontal—that are oriented on different planes.
44.5K
Major Somatic Sensory Pathways01:28

Major Somatic Sensory Pathways

3.2K
Sensory impulses related to touch, pressure, vibration, and proprioception from various body parts, such as the limbs, trunk, neck, and posterior head, travel to the cerebral cortex through the posterior column-medial lemniscus pathway. The pathway’s name derives from the two white-matter tracts that convey the impulses: the spinal cord's posterior column and the brainstem's medial lemniscus. First-order sensory neurons extend their axons into the spinal cord, forming the...
3.2K
Chemotherapy-Induced Nausea and Vomiting: Dopamine Receptor Antagonists01:29

Chemotherapy-Induced Nausea and Vomiting: Dopamine Receptor Antagonists

992
Dopamine receptor antagonists, also known as antipsychotic agents, are critical in managing chemotherapy-induced vomiting. These antiemetic agents block dopamine receptors in the chemoreceptor trigger zone (CTZ), inhibiting signal transmission to the vomiting center. Antipsychotic agents encompass phenothiazines (PTZ), butyrophenones, benzamides, and thienobenzodiazepines (Zyprexa), which are utilized for their antiemetic and sedative properties.
Phenothiazines, such as prochlorperazine...
992

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Expert Clinical Consensus on Body Surface Gastric Mapping Phenotypes for Gastroduodenal Disorders: 'Auckland Classification' v1.0.

Neurogastroenterology and motility·2026
Same author

Effect of icosapent ethyl treatment on colorectal tissue marine omega-3 polyunsaturated fatty acid levels among patients with a history of adenoma: a prospective, single-arm clinical trial.

The American journal of clinical nutrition·2026
Same author

A new in silico model to precisely design focused ultrasound brain therapies.

Medical physics·2026
Same author

A Multicenter, Sham-Controlled, Pilot, Randomized Controlled Trial of Interferential Therapy for the Treatment of Chronic Constipation.

Journal of clinical gastroenterology·2026
Same author

Avoidant/Restrictive Food Intake Disorder Is Common in Adult and Pediatric Patients with Celiac Disease and Non-Celiac Gluten Sensitivity.

Nutrients·2026
Same author

Randomized Sham-Controlled Trial of Translumbosacral Neuromodulation Therapy for Fecal Incontinence.

Gastroenterology·2026

Related Experiment Video

Updated: Mar 7, 2026

Assessing the Autonomic and Behavioral Effects of Passive Motion in Rats using Elevator Vertical Motion and Ferris-Wheel Rotation
06:18

Assessing the Autonomic and Behavioral Effects of Passive Motion in Rats using Elevator Vertical Motion and Ferris-Wheel Rotation

Published on: February 7, 2020

9.0K

Motion sickness increases functional connectivity between visual motion and nausea-associated brain regions.

Nicola Toschi1,2, Jieun Kim1,3, Roberta Sclocco1,4

  • 1Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, MA.

Autonomic Neuroscience : Basic & Clinical
|March 2, 2017
PubMed
Summary

Motion sickness alters brain connectivity, enhancing communication between visual motion areas and nausea centers. This increased coupling may drive nausea perception and sympathetic responses, offering targets for intervention.

Keywords:
Brain connectivityBrain-gut interactionsHeart rate variabilityMT+/V5Sympathovagal balance

More Related Videos

How to Study Placebo Responses in Motion Sickness with a Rotation Chair Paradigm in Healthy Participants
08:50

How to Study Placebo Responses in Motion Sickness with a Rotation Chair Paradigm in Healthy Participants

Published on: December 14, 2014

9.7K
Using Eye-tracking to Assess the Relative Importance of Visual and Vestibular Input to Subcortical Motion Processing in the Roll Plane
07:24

Using Eye-tracking to Assess the Relative Importance of Visual and Vestibular Input to Subcortical Motion Processing in the Roll Plane

Published on: August 22, 2025

598

Related Experiment Videos

Last Updated: Mar 7, 2026

Assessing the Autonomic and Behavioral Effects of Passive Motion in Rats using Elevator Vertical Motion and Ferris-Wheel Rotation
06:18

Assessing the Autonomic and Behavioral Effects of Passive Motion in Rats using Elevator Vertical Motion and Ferris-Wheel Rotation

Published on: February 7, 2020

9.0K
How to Study Placebo Responses in Motion Sickness with a Rotation Chair Paradigm in Healthy Participants
08:50

How to Study Placebo Responses in Motion Sickness with a Rotation Chair Paradigm in Healthy Participants

Published on: December 14, 2014

9.7K
Using Eye-tracking to Assess the Relative Importance of Visual and Vestibular Input to Subcortical Motion Processing in the Roll Plane
07:24

Using Eye-tracking to Assess the Relative Importance of Visual and Vestibular Input to Subcortical Motion Processing in the Roll Plane

Published on: August 22, 2025

598

Area of Science:

  • Neuroscience
  • Human Physiology
  • Cognitive Science

Background:

  • Brain networks underlying nausea remain unclear.
  • Previous work identified sustained activation in anterior insula (aIns) and mid-cingulate (MCC) cortices during nausea.
  • Visual motion processing areas (V1, MT+/V5) are activated by visual stimuli.

Purpose of the Study:

  • To investigate if motion sickness alters functional connectivity between visual motion and nausea-processing brain regions.
  • To examine changes in connectivity during a motion sickness provocation task.
  • To correlate connectivity changes with autonomic nervous system responses.

Main Methods:

  • Functional magnetic resonance imaging (fMRI) and electrocardiography (ECG) were used during a motion sickness task.
  • Connectivity was analyzed between visual areas (V1, MT+/V5) and nausea regions (aIns, MCC) at rest (BASELINE) versus peak nausea (NAUSEA).
  • Heart rate variability (HRV) assessed sympathovagal balance.

Main Results:

  • During peak nausea, connectivity decreased between V1 regions but increased between visual motion areas (MT+/V5) and nausea regions (aIns, MCC).
  • The change in MT+/V5-insula connectivity correlated with altered sympathovagal balance.
  • No significant state-related connectivity changes were observed in controls.

Conclusions:

  • Vection-induced nausea enhances connectivity between visual motion processing and nausea/salience networks.
  • This increased coupling may facilitate the transfer of sensory mismatch information, supporting nausea perception and sympathetic activation.
  • Targeting this enhanced connectivity could be key for motion sickness interventions.