Polarized Exocytosis
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Updated: Mar 7, 2026
Quantifying Spatiotemporal Parameters of Cellular Exocytosis in Micropatterned Cells
Published on: September 16, 2020
Jingwen Zeng1, Shanshan Feng2, Bin Wu1
1Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6018.
Abstract:
Polarized exocytosis is generally considered as the multistep vesicular trafficking process in which membrane-bounded carriers are transported from the Golgi or endosomal compartments to specific sites of the plasma membrane. Polarized exocytosis in cells is achieved through the coordinated actions of membrane trafficking machinery and cytoskeleton orchestrated by signaling molecules such as the Rho family of small GTPases. Elucidating the molecular mechanisms of polarized exocytosis is essential to our understanding of a wide range of pathophysiological processes from neuronal development to tumor invasion.
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