Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Allergic Reactions02:06

Allergic Reactions

33.1K
Overview
33.1K
Allergic Drug Reactions01:27

Allergic Drug Reactions

1.5K
Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...
1.5K
Allergic Reactions: Anaphylaxis01:30

Allergic Reactions: Anaphylaxis

92
Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin,...
92
Cross-reactivity00:42

Cross-reactivity

33.6K
Overview
33.6K
Hypersensitivity Reactions: Delayed Hypersensitivity Reactions01:29

Hypersensitivity Reactions: Delayed Hypersensitivity Reactions

97
Delayed-Type Hypersensitivity (DTH), or Type IV hypersensitivity, is a cell-mediated immune response. It occurs when T cells, rather than antibodies, mediate a reaction to specific antigens. It is characterized by a delayed onset (1-2 days) and involves the recruitment of macrophages to the inflammation site.The initiation of a DTH response begins with the sensitization of T cells. During this phase, which lasts at least 1-2 weeks, antigen-specific T cells are activated, clonally expanded, and...
97
Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs01:25

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

2.1K
Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
2.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Summertime methane and carbon dioxide emission rates and associated variables from a national-scale survey of 146 reservoirs in the United States.

Limnology and oceanography letters·2026
Same author

Virtual joint school prior to hip and knee arthroplasty: patient feedback and carbon footprint savings.

Annals of the Royal College of Surgeons of England·2026
Same author

Integrated fire management as an adaptation and mitigation strategy to altered fire regimes.

Communications earth & environment·2025
Same author

Sleep problems and associations with psychopathology and cognition in young people with 22q11.2 deletion syndrome (22q11.2DS).

Psychological medicine·2019
Same author

The Mdm1 Locus and Maize Resistance to Maize dwarf mosaic virus.

Plant disease·2019
Same author

Cytotoxic efficacy of filanesib and melphalan combination is governed by sequence of treatment in human myeloma cells.

Blood cancer journal·2016
Same journal

Comparative performance of the risk analysis index versus traditional frailty measures in predicting outcomes following revision total hip arthroplasty for mechanical prosthetic complications.

Hip international : the journal of clinical and experimental research on hip pathology and therapy·2026
Same journal

The true fate of the 2-stage revision arthroplasty for hip and knee prosthetic joint infection.

Hip international : the journal of clinical and experimental research on hip pathology and therapy·2026
Same journal

Approach-specific learning curves for operative efficiency in robotic-assisted total hip arthroplasty.

Hip international : the journal of clinical and experimental research on hip pathology and therapy·2026
Same journal

Short-term survivorship of a novel acetabular component with a combination of non-locking and variable-angle locking screws in complex acetabular reconstruction.

Hip international : the journal of clinical and experimental research on hip pathology and therapy·2026
Same journal

The impact of hip geometrical parameters on muscle and joint biomechanics during normal gait.

Hip international : the journal of clinical and experimental research on hip pathology and therapy·2026
Same journal

Relationship of wound cosmesis with patient-reported outcome measures following total hip arthroplasty.

Hip international : the journal of clinical and experimental research on hip pathology and therapy·2026
See all related articles

Related Experiment Video

Updated: Mar 7, 2026

Antigenic Liposomes for Generation of Disease-specific Antibodies
10:31

Antigenic Liposomes for Generation of Disease-specific Antibodies

Published on: October 25, 2018

12.9K

Palacos and peanut allergy.

M Ganapathi1, M W Jones, R S H Pumphrey

  • 1Department of Orthopaedics, Ysbyty Gwynedd, Bangor - UK.

Hip International : the Journal of Clinical and Experimental Research on Hip Pathology and Therapy
|March 2, 2017
PubMed
Summary
This summary is machine-generated.

Orthopaedic surgeons were largely unaware that Palacos bone cement contains peanut oil. Despite manufacturer warnings, the clinical significance of this contraindication for peanut-allergic patients remains uncertain.

More Related Videos

Basophil Activation Test for Allergy Diagnosis
07:22

Basophil Activation Test for Allergy Diagnosis

Published on: May 31, 2021

9.7K
Author Spotlight: Quantification of Aflatoxins and Phytoalexins in Peanut Seeds to Identify Genetic Resistance Against Aspergillus
10:24

Author Spotlight: Quantification of Aflatoxins and Phytoalexins in Peanut Seeds to Identify Genetic Resistance Against Aspergillus

Published on: April 19, 2024

1.7K

Related Experiment Videos

Last Updated: Mar 7, 2026

Antigenic Liposomes for Generation of Disease-specific Antibodies
10:31

Antigenic Liposomes for Generation of Disease-specific Antibodies

Published on: October 25, 2018

12.9K
Basophil Activation Test for Allergy Diagnosis
07:22

Basophil Activation Test for Allergy Diagnosis

Published on: May 31, 2021

9.7K
Author Spotlight: Quantification of Aflatoxins and Phytoalexins in Peanut Seeds to Identify Genetic Resistance Against Aspergillus
10:24

Author Spotlight: Quantification of Aflatoxins and Phytoalexins in Peanut Seeds to Identify Genetic Resistance Against Aspergillus

Published on: April 19, 2024

1.7K

Area of Science:

  • Orthopaedic surgery
  • Biomaterials science
  • Allergy and immunology

Background:

  • Palacos bone cement contains peanut oil, necessitating a contraindication for patients with peanut allergies.
  • Orthopaedic surgeons' awareness of this ingredient and its implications is crucial for patient safety.

Purpose of the Study:

  • To assess orthopaedic surgeons' awareness of peanut oil in Palacos cement.
  • To evaluate the clinical relevance of the manufacturer's peanut allergy warning.

Main Methods:

  • A postal questionnaire was distributed to orthopaedic surgeons.
  • The questionnaire aimed to gauge awareness regarding Palacos cement composition.

Main Results:

  • A significant majority (73%) of responding surgeons were unaware of peanut oil in Palacos cement.
  • This highlights a potential gap in knowledge within the orthopaedic community.

Conclusions:

  • There is a low level of awareness among orthopaedic surgeons regarding peanut oil in Palacos cement.
  • The clinical necessity of the peanut allergy warning requires further investigation based on existing literature.