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[High doses of trospium chloride in patients with idiopathic overactive bladder. Data of large-scale, multicenter
G G Krivoborodov1, E I Tur1, N S Efremov1
1Department of Faculty Surgery, Urology of the Medical Faculty RNSMU n.a. N.I. Pirogov, RCRC of Gerontology.
Purpose:
Evaluation of the efficacy and safety of different doses of trospium chloride in patients with idiopathic overactive bladder.
Materials And Methods:
Large-scale observational program "Resource" included 669 patients with idiopathic OAB - 359 women and 310 men. At the first visit, all patients were assigned to use of trospium chloride at a standard dose of 45 mg per day. The results of treatment were evaluated during follow-up visits at 3, 6, 9 and 12 weeks. Depending on the results of examination, the dose was reduced in the presence of adverse events and increased in case of insufficient treatment effects.
Results:
After 12 weeks, 102 patients have been receiving the drug at a dose of 30 mg/day, 241 - at a dose of 45 mg/day, 257 - at a dose of 60 mg/day, and 22 - at a dose of 75 mg/day.
Conclusions:
Individual approach to the selection of doses of trospium chloride in patients with idiopathic OAB can be quite effective and safe measure to achieve optimal clinical outcome with a good safety profile.
