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Updated: Mar 7, 2026
Cardiac Magnetic Resonance Imaging at 7 Tesla
Published on: January 6, 2019
Noninvasive Determination of HV Interval Using Magnetocardiography
Sengottuvel Senthilnathan1, Raja J Selvaraj2, Rajesh Patel1
1Magnetoencephalography Laboratory, SQUIDs and Applications Section, Materials Science Group, Indira Gandhi Centre for Atomic Research, Kalpakkam, Tamil Nadu, India.
Background:
The His-ventricular (HV) interval is an important index of atrioventricular conduction, but at present can be reliably measured only during an invasive electrophysiology (EP) study. Magnetocardiography (MCG) is a noninvasive measurement of weak magnetic fields generated by the heart. We compared HV interval noninvasively assessed using MCG with the corresponding values measured directly in an EP study.
Methods:
MCG was measured using a 37-channel system inside a magnetically shielded room in patients who had previously undergone an EP study. His-bundle potential was identified in the PR segment after signal averaging. Magnetic field maps representing the spatial distribution of ramp-like signals in the PR segment generated at various instants of time were used to identify His-bundle signals in cases where the deflection representing the His was ambiguous.
Results:
The study included 23 patients (14 male, nine female) with a wide range of HV intervals measured during EP study (49 ± 17 ms, range 35-120 ms). In 21 (91%) subjects, discernible His-bundle signals are observed in the PR segment of MCG traces. HV intervals measured between the two methods showed a correlation (r2 = 0.87, P < 0.0001) with a mean difference of 5.4 ± 3.2 ms.
Conclusion:
With the use of new criteria to identify the His-bundle deflection in signal-averaged MCG signals, we report a high success rate in noninvasive HV interval measurement and a good agreement with those from EP study. The results encourage the use of MCG as a noninvasive method for measurement of the HV interval.
