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In Situ Characterization of Hydrated Proteins in Water by SALVI and ToF-SIMS
Published on: February 15, 2016
Water Dynamics in the Hydration Shells of Biomolecules
Damien Laage1,2, Thomas Elsaesser3, James T Hynes1,2,4
1École Normale Supérieure, PSL Research University, UPMC Univ Paris 06, CNRS , Département de Chimie, PASTEUR, 24 rue Lhomond, 75005 Paris, France.
None:
The structure and function of biomolecules are strongly influenced by their hydration shells. Structural fluctuations and molecular excitations of hydrating water molecules cover a broad range in space and time, from individual water molecules to larger pools and from femtosecond to microsecond time scales. Recent progress in theory and molecular dynamics simulations as well as in ultrafast vibrational spectroscopy has led to new and detailed insight into fluctuations of water structure, elementary water motions, electric fields at hydrated biointerfaces, and processes of vibrational relaxation and energy dissipation. Here, we review recent advances in both theory and experiment, focusing on hydrated DNA, proteins, and phospholipids, and compare dynamics in the hydration shells to bulk water.
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