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Continuous Intravenous Milrinone Therapy in Pediatric Outpatients
Michelle Curley1, Jill Liebers, Roy Maynard
1Pediatric Home Service (Ms Curley and Dr Liebers), and Children's Hospitals and Clinics of Minnesota (Dr Maynard). Michelle Curley, RN, CRNI®, is an infusion nurse manager at Pediatric Home Service, Roseville, MN. Jill Liebers, PharmD, is a pharmacy manager at Pediatric Home Service, Roseville, MN. Roy Maynard, MD, is a practicing pediatric pulmonologist on staff at Children's Hospitals and Clinics of Minnesota, Minneapolis, MN. He is also the medical director at Pediatric Home Service, Roseville, MN.
This review explores the benefits of continuous outpatient milrinone therapy for pediatric heart failure patients. It highlights potential uses including cardiac dysfunction, transplant, and palliative care.
Area of Science:
- Cardiology
- Pharmacology
Background:
- Milrinone is a phosphodiesterase 3 inhibitor.
- It possesses positive inotropic and vasodilator properties.
- It is indicated for short-term acute decompensated heart failure treatment.
Purpose of the Study:
- To review medical literature on pediatric outpatient milrinone therapy.
- To describe a home infusion company's experience with this therapy.
- To explore milrinone's potential in pediatric cardiac dysfunction, transplant, and palliative care.
Main Methods:
- Literature review.
- Retrospective analysis of a home infusion company's data.
- Case study approach.
Main Results:
- Limited data exists for long-term adult milrinone therapy.
- Pediatric outpatients may benefit from continuous milrinone.
- Potential applications include cardiac dysfunction, destination therapy, and palliative care.
Conclusions:
- Continuous outpatient milrinone therapy shows promise for pediatric patients.
- Further research is needed to support long-term use.
- Home infusion models can facilitate this treatment.
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