Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Anticoagulant Drugs: Low-Molecular-Weight Heparins01:30

Anticoagulant Drugs: Low-Molecular-Weight Heparins

2.2K
Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
2.2K
Venous Thrombosis III: Interprofessional Care01:29

Venous Thrombosis III: Interprofessional Care

431
Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
431
Disorders of Hemostasis01:24

Disorders of Hemostasis

2.5K
Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
2.5K
Venous Thrombosis I: Introduction01:30

Venous Thrombosis I: Introduction

599
Venous thrombosis, the most common disorder of the veins, involves the formation of a thrombus or blood clot associated with vein inflammation. It can be classified as either superficial vein thrombosis or deep vein thrombosis.Superficial Vein Thrombosis: This involves the formation of a thrombus in a superficial vein, usually the greater or lesser saphenous vein. Though less severe than deep vein thrombosis (DVT), SVT can lead to complications if untreated.Deep Vein Thrombosis (DVT): This...
599
Introduction to Hemostasis01:05

Introduction to Hemostasis

15.6K
Hemostasis is a complex physiological process that prevents excessive bleeding when a blood vessel is injured. It's crucial for maintaining the integrity of the circulatory system, as it ensures that our blood remains fluid while still within the vascular network and yet clots to prevent blood loss upon vessel injury.
The three phases of hemostasis involve many clotting factors present in plasma and several substances released by platelets and injured tissue cells. It is a fast, localized,...
15.6K
Formation of the Platelet Plug01:22

Formation of the Platelet Plug

10.2K
The platelet phase, the second stage of hemostasis, commences around 15-20 seconds after an injury. It follows and overlaps with the vascular phase, during which blood vessels constrict to minimize blood loss.
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...
10.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Metabolic Syndrome.

Medsurg nursing : official journal of the Academy of Medical-Surgical Nurses·2015
Same author

Heparin-induced thrombocytopenia.

Medsurg nursing : official journal of the Academy of Medical-Surgical Nurses·2014
Same author

Hyperglycemic state.

Medsurg nursing : official journal of the Academy of Medical-Surgical Nurses·2012
Same author

Prevent infections with good denture care.

Nursing·2009
Same journal

Incidence and Risk Factors of Catheter-Related Thrombosis in Oncology Patients With Internal Jugular and Subclavian Implanted Ports: A Retrospective Single-Center Study.

Journal of infusion nursing : the official publication of the Infusion Nurses Society·2026
Same journal

Approaches to Teaching Peripheral Venous Puncture: A Scoping Review.

Journal of infusion nursing : the official publication of the Infusion Nurses Society·2026
Same journal

Intravenous Sodium Bicarbonate: An Overview of Its Evolving Role in Metabolic Acidosis, Safety Concerns, and Administration Considerations.

Journal of infusion nursing : the official publication of the Infusion Nurses Society·2026
Same journal

Effectiveness of Ethylene Tetrafluoroethylene (ETFE) and Polypropylene (PP) Peripheral Intravenous Catheter Biomaterials on the Incidence of Phlebitis.

Journal of infusion nursing : the official publication of the Infusion Nurses Society·2026
Same journal

The Effect of Jet Lidocaine on Pain and Anxiety During Peripheral Venous Access: A Systematic Review and Meta-Analysis.

Journal of infusion nursing : the official publication of the Infusion Nurses Society·2026
Same journal

Advancing Excellence in Infusion Nursing: Reflections From the 2026 INS Annual Meeting.

Journal of infusion nursing : the official publication of the Infusion Nurses Society·2026
See all related articles

Related Experiment Video

Updated: Mar 7, 2026

A Uniform Shear Assay for Human Platelet and Cell Surface Receptors via Cone-plate Viscometry
04:32

A Uniform Shear Assay for Human Platelet and Cell Surface Receptors via Cone-plate Viscometry

Published on: June 5, 2019

8.2K

Heparin-Induced Thrombocytopenia.

Cynthia A Frazer1

  • 1Eastern Kentucky University, Department of Associate Degree Nursing, Richmond, Kentucky. Cynthia A. Frazer, MS, RN, CNE, CMSRN, is an associate professor in the department of associate degree nursing at Eastern Kentucky University where she teaches medical-surgical nursing.

Journal of Infusion Nursing : the Official Publication of the Infusion Nurses Society
|March 2, 2017
PubMed
Summary
This summary is machine-generated.

Heparin-induced thrombocytopenia (HIT) is an immune reaction to heparin therapy, posing a risk for nurses using heparin in vascular access devices. Understanding HIT risk factors, its mechanisms, and management is crucial for patient safety.

More Related Videos

Surface Engineering of Pancreatic Islets with a Heparinized StarPEG Nanocoating
05:35

Surface Engineering of Pancreatic Islets with a Heparinized StarPEG Nanocoating

Published on: June 23, 2018

7.8K
Comprehensive Analysis of Procoagulant Platelets Exhibiting Features of Necrosis, Apoptosis and Platelet Activation
04:37

Comprehensive Analysis of Procoagulant Platelets Exhibiting Features of Necrosis, Apoptosis and Platelet Activation

Published on: May 23, 2025

1.2K

Related Experiment Videos

Last Updated: Mar 7, 2026

A Uniform Shear Assay for Human Platelet and Cell Surface Receptors via Cone-plate Viscometry
04:32

A Uniform Shear Assay for Human Platelet and Cell Surface Receptors via Cone-plate Viscometry

Published on: June 5, 2019

8.2K
Surface Engineering of Pancreatic Islets with a Heparinized StarPEG Nanocoating
05:35

Surface Engineering of Pancreatic Islets with a Heparinized StarPEG Nanocoating

Published on: June 23, 2018

7.8K
Comprehensive Analysis of Procoagulant Platelets Exhibiting Features of Necrosis, Apoptosis and Platelet Activation
04:37

Comprehensive Analysis of Procoagulant Platelets Exhibiting Features of Necrosis, Apoptosis and Platelet Activation

Published on: May 23, 2025

1.2K

Area of Science:

  • Immunology
  • Pharmacology
  • Nursing Practice

Background:

  • Heparin-induced thrombocytopenia (HIT) is a serious immune-mediated adverse effect of heparin administration.
  • Heparin is frequently used for vascular access device patency, making HIT a relevant concern in nursing.
  • Infusion nurses must be aware of HIT due to its potential complications.

Purpose of the Study:

  • To review the key risk factors associated with the development of HIT.
  • To elucidate the underlying pathophysiology of heparin-induced thrombocytopenia.
  • To outline current management strategies for patients experiencing HIT.

Main Methods:

  • Literature review of existing studies on heparin-induced thrombocytopenia.
  • Analysis of risk factors, clinical presentation, and diagnostic criteria for HIT.
  • Synthesis of evidence-based recommendations for HIT management.

Main Results:

  • HIT is triggered by antibodies against heparin and platelet factor 4 (PF4).
  • Risk factors include type of heparin, duration of therapy, and patient-specific elements.
  • Early recognition and cessation of heparin are critical for management.

Conclusions:

  • HIT is a significant complication requiring vigilant monitoring by healthcare professionals, especially nurses.
  • Understanding HIT pathophysiology aids in timely diagnosis and intervention.
  • Effective management protocols are essential to mitigate HIT-related morbidity and mortality.