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Disorders of the Nervous Tissue01:28

Disorders of the Nervous Tissue

2.9K
Nervous tissue is a vital component of the human body's communication system, enabling us to perceive and respond to stimuli. However, like all other tissues, it is vulnerable to disorders and diseases that can significantly impact our neurological functioning.
Homeostatic Imbalances:
Alzheimer's disease manifests as a gradual decline in memory and cognitive abilities, attributed to the buildup of amyloid plaques and neurofibrillary tangles in the brain.
Parkinson's disease arises from the...
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Disorders of the Skeletal Muscle01:28

Disorders of the Skeletal Muscle

2.1K
The clinical conditions affecting the skeletal muscle tissue are broadly categorized as musculoskeletal and neuromuscular disorders.
Musculoskeletal disorders
Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...
2.1K
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

5.9K
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
5.9K
Disorders of the Autonomic Nervous System01:18

Disorders of the Autonomic Nervous System

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The autonomic nervous system (ANS) is an intricate network of nerves that controls functions such as the regulation of heart rate, digestion, and blood pressure regulation. When this system malfunctions, it can lead to various disorders that affect multiple bodily functions. One common feature of many autonomic disorders is the involvement of smooth blood vessels, which play a crucial role in regulating blood flow throughout the body.
Raynaud's disease, also known as Raynaud's...
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Sex-linked Disorders01:43

Sex-linked Disorders

110.0K
Like autosomes, sex chromosomes contain a variety of genes necessary for normal body function. When a mutation in one of these genes results in biological deficits, the disorder is considered sex-linked.
110.0K
Nightmares and Night Terrors01:18

Nightmares and Night Terrors

671
Nightmares and night terrors represent two distinct types of sleep disturbances that differ in timing, characteristics, and the sleeper's recall of the event. Nightmares are vivid, disturbing dreams that usually awaken the sleeper from REM sleep, a stage of sleep where brain activity is high, and dreams are most frequent. Upon awakening, individuals often have detailed recollections of their nightmares, which can include themes of threats to survival, security, or self-esteem.
Nightmares...
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Related Experiment Video

Updated: Mar 7, 2026

A Battery of Motor Tests in a Neonatal Mouse Model of Cerebral Palsy
10:02

A Battery of Motor Tests in a Neonatal Mouse Model of Cerebral Palsy

Published on: November 3, 2016

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Neurocutaneous Disorders in Children.

Bruce R Korf1, E Martina Bebin2

  • 1Departments of Genetics and.

Pediatrics in Review
|March 3, 2017
PubMed
Summary

Neurocutaneous disorders like neurofibromatosis (NF) and tuberous sclerosis complex (TSC) require early recognition for managing complications. Advances in understanding pathogenesis are paving the way for targeted therapies.

Area of Science:

  • Pediatrics
  • Genetics
  • Neurology

Background:

  • Neurocutaneous disorders, including neurofibromatosis (NF) types 1 and 2, schwannomatosis, tuberous sclerosis complex (TSC), and Sturge-Weber syndrome, are typically diagnosed in childhood.
  • Early identification by pediatricians is crucial for monitoring treatable complications and facilitating genetic counseling.

Purpose of the Study:

  • To highlight the importance of early recognition of neurocutaneous disorders.
  • To discuss diagnostic methods, including clinical evaluation and genetic testing.
  • To provide an overview of current symptomatic treatments and emerging molecularly targeted therapies.

Main Methods:

  • Clinical diagnosis based on characteristic features.
  • Genetic testing to confirm diagnosis and aid in genetic counseling.

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  • Review of current therapeutic approaches and emerging research in pathogenesis.
  • Main Results:

    • Early recognition enables timely surveillance for potential complications.
    • Genetic testing offers clarity for uncertain diagnoses and supports family counseling.
    • While many complications are managed symptomatically, new targeted therapies are under development.

    Conclusions:

    • Prompt diagnosis of neurocutaneous disorders is essential for effective patient management.
    • Genetic testing plays a vital role in diagnosis and counseling.
    • Understanding disease pathogenesis is driving the development of novel, potentially disease-altering treatments.