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Updated: Mar 6, 2026

Evaluation of Polymeric Gene Delivery Nanoparticles by Nanoparticle Tracking Analysis and High-throughput Flow Cytometry

Evaluation of Polymeric Gene Delivery Nanoparticles by Nanoparticle Tracking Analysis and High-throughput Flow Cytometry

Published on: March 1, 2013

Polysaccharide-based Nanoparticles for Gene Delivery.

Myung Sook Huh¹, Eun Jung Lee¹, Heebeom Koo²

¹Center for Theragnosis, Biomedical Research Institute, Korea Institute of Science and Technology (KIST), Hwarangno 14-gil 5, Seongbuk-gu, Seoul, 136-791, Republic of Korea.

Topics in Current Chemistry (Cham)

|March 3, 2017

Summary

This summary is machine-generated.

Polysaccharide-based nanoparticles offer biocompatible and biodegradable drug delivery systems. These advanced nanotechnology carriers show significant promise for efficient gene delivery applications in biotechnology.

Keywords:

Gene delivery Nanomedicine Nanoparticle Nanotechnology Polysaccharide siRNA delivery

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Area of Science:

Biomedical Engineering
Materials Science
Drug Delivery Systems

Background:

Nanoparticles are effective carriers for biopharmaceutical agents like proteins and genes.
Polysaccharides are increasingly researched for drug delivery due to biocompatibility, biodegradability, and low toxicity.

Purpose of the Study:

To review the chemical and physical properties of polysaccharides for biomedical use.
To discuss advancements in polysaccharide-based nanoparticles for gene delivery.

Main Methods:

Literature review of polysaccharide-based nanoparticles.
Analysis of chemical and physical properties of various polysaccharides.
Discussion of recent developments in gene delivery applications.

Main Results:

Polysaccharides like chitosan, hyaluronic acid, and dextran are suitable polymeric backbones for nanoparticle formation.
These nanoparticles demonstrate potential as effective gene delivery vehicles.

Conclusions:

Polysaccharide-based nanoparticles represent a promising platform for advanced gene therapy.
Further research into these materials can optimize drug delivery efficacy and safety.