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Enhancing cognitive behavioral therapy: Is the finish line in sight?
1Emory University, Department of Psychiatry & Behavioral Sciences, Yerkes National Primate Research Center, Atlanta, GA 30322, USA.
Science Translational Medicine
|March 3, 2017
Summary
Augmenting cognitive behavioral therapy with D-cycloserine (DCS) slightly reduced anxiety disorder symptoms. This finding suggests DCS may enhance traditional therapy for anxiety.
Area of Science:
- Psychiatry
- Neuroscience
- Pharmacology
Background:
- Anxiety disorders are prevalent mental health conditions.
- Cognitive behavioral therapy (CBT) is a first-line treatment.
- Novel therapeutic augmentation strategies are needed.
Purpose of the Study:
- To investigate the efficacy of D-cycloserine (DCS) as an adjunct to CBT for anxiety disorders.
- To assess the impact of DCS on symptom severity.
Main Methods:
- Systematic review and meta-analysis of randomized controlled trials.
- Inclusion of studies evaluating CBT augmentation with DCS versus placebo.
- Analysis of symptom severity scores as the primary outcome.
Main Results:
- Augmentation of CBT with DCS showed a small but statistically significant decrease in anxiety symptom severity.
- Effect size was modest, indicating a minor clinical benefit.
- No significant differences in adverse events were noted.
Conclusions:
- D-cycloserine (DCS) may offer a modest benefit when combined with cognitive behavioral therapy (CBT) for anxiety disorders.
- Further research is warranted to optimize dosage and identify patient subgroups who may benefit most.
- DCS represents a potential, albeit small, addition to the anxiety treatment દવા armamentarium.
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