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Updated: Jun 23, 2026

Pretargeted Radioimmunotherapy Based on the Inverse Electron Demand Diels-Alder Reaction
Published on: January 29, 2019
Localization matters: a nuclear targeting two-photon absorption iridium complex in photodynamic therapy
Xiaohe Tian1, Yingzhong Zhu2, Mingzhu Zhang1
1School of Life Science, Anhui University, Hefei 230039, P. R. China. xiaohe.t@ahu.edu.cn and Department of Chemistry, Key Laboratory of Functional Inorganic Material Chemistry of Anhui Province, Anhui University, Hefei 230039, P. R. China. yptian@ahu.edu.cn.
Abstract:
We present a two-photon (2P, 800 nm) PDT cyclometalated Iridium(iii) complex (Ir-Es) that targets the intracellular nucleus. The complex is capable of migrating sequentially from the nucleus to mitochondria and inducing dual-damage under light exposure. This study suggests that with minor modification of the terminal moieties of complexes, their final intracellular destinations and PDT efficiency can be significantly impacted.
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