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Updated: Mar 6, 2026
10:29
Simulating Pancreatic Neuroplasticity: In Vitro Dual-neuron Plasticity Assay
Published on: April 14, 2014
10.3K
Pancreatic neuroendocrine tumors
Modesto Varas Lorenzo1, Esteban Cugat Andorra2, Jaume Capdevila Castillón3
1Digestivo y Unidad Ecoendoscopia, Centro Médico Teknon, España.
Revista Espanola De Enfermedades Digestivas
|March 4, 2017
Summary
Neuroendocrine tumors (PNET) are increasingly common, with non-functioning PNETs (NF-PNETs) being the most frequent type. This study observed a higher prevalence of NF-PNETs in a recent series compared to historical data.
Area of Science:
- Endocrinology
- Oncology
- Gastroenterology
Background:
- Pancreatic neuroendocrine tumors (PNET) were first described in the 1950s.
- PNETs can be sporadic or linked to hereditary syndromes, and present as benign or malignant, functioning or non-functioning types.
- Non-functioning PNETs (NF-PNETs) are the most prevalent subtype, with reported frequencies ranging from 50% to 91%.
Discussion:
- This study analyzed 70 cases of PNETs.
- A significant proportion (33%) of tumors in the current series were malignant.
- Slightly over half the cases (52%) underwent surgical intervention.
Key Insights:
- The prevalence of NF-PNETs in the current series was 72%.
- This represents a notable increase compared to the 37% prevalence observed in historical series.
- The findings suggest a potential rise in the occurrence or detection of NF-PNETs over time.
Outlook:
- Further research is warranted to understand the factors contributing to the increased prevalence of NF-PNETs.
- Investigating diagnostic advancements and screening protocols may elucidate this trend.
- Long-term outcome analysis for operated and non-operated cases will be valuable.
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